The Aspartic Protease Ddi1 Contributes to DNA-Protein Crosslink Repair in Yeast

Article Article scientifique Article The Aspartic Protease Ddi1 Contributes to DNA-Protein Crosslink Repair in Yeast eng 2020 author Serbyn Nataliia 815112 author Noireterre Audrey 0000-0002-3848-6363 891737 author Bagdiul Ivona 668403 author Plank Michaël 857393 author Michel Agnès H. author Loewith Robbie Joséph 630703 author Kornmann Benoît author Stutz Françoise 64881 1066-1079 10.1016/j.molcel.2019.12.007 31902667 1097-2765 https://linkinghub.elsevier.com/retrieve/pii/S1097276519308986 Proteolysis facilitates the efficient disassembly of otherwise extremely toxic DNA-protein covalent crosslinks. Serbyn et al. show that the aspartic protease Ddi1 protects cells against a broad variety of such crosslinks and further investigate how Ddi1 coordinates with known proteolytic mechanisms involved in their elimination. Ddi1 DNA-protein crosslink Wss1 Protease Top1 Flp recombinase 26S proteasome RNA Polymerase II Rpb1 Yeast Dewey 570 Swiss National Science Foundation Role of antisense transcription in gene regulation and importance of ubiquitination and sumoylation in mRNA biogenesis and export during yeast cell cycle progression. 153331 CH Projects Swiss National Science Foundation Effect of yeast pervasive transcription on gene regulation and replication, and link between nuclear organization, sumoylation and resolution of DNA-protein covalent complexes 182344 CH Projects Swiss National Science Foundation NCCR Chemical Biology - Visualisation and Control of Biological Processes Using Chemistry (phase III) 185898 CH Programmes 43 Département de biologie moléculaire 161 46 Département de biologie cellulaire 165 false 814 Groupe Loewith 839 Groupe Stutz Molecular Cell 77 5 86cacedc-767c-49b2-9f30-e8c473874906 Article (Published version) Restricted Serbyn_MolCell_2020.pdf 29861792 application/pdf Private 2021-06-18 restrictedAccess Faculté des sciences / Section de biologie / Département de biologie moléculaire Faculté des sciences / Section de biologie / Département de biologie cellulaire

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Ubx5‐Cdc48 assists the protease Wss1 at DNA‐protein crosslink sites in yeast	EMBO journal	2023	85	124
The Aspartic Protease Ddi1 Contributes to DNA-Protein Crosslink Repair in Yeast	Molecular Cell	2020	393	1

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Bagdiul, Ivona