Medullary-like hepatocellular carcinoma

Article Article scientifique Rapport de cas Medullary-like hepatocellular carcinoma eng 2018 author Cristaudi Alessandra author Barizzi Jessica 667914 author Rosso Raffaele author Varini Marco author Alerci Mario author Rubbia-Brandt Laura 31809 author Majno Pietro 80596 author Balzarotti Canger Ruben Carlo rjy010 10.1093/jscr/rjy010 29435219 2042-8812 Hepatocellular carcinoma (HCC) is the most frequent primary hepatic cancer. Pathological features can define the biological behavior and prognosis. Medullary-like HCC is a very rare variant that has been described only twice in literature. In the present study, we report the case of a non-cirrhotic 72-year-old man, who presented two HCC lesions on routine screening for hepatitis C virus liver disease. Radiological imaging and biopsy showed two different subtypes: one classic HCC, which was treated with chemoembolization, and a second PET/CT-positive carcinoma with a PET/CT-positive metastatic coeliac lymph node, which was resected laparoscopically with a left lateral sectionectomy and extended lymphadenectomy. Histopathology revealed a medullary-like HCC; lymph node analysis confirmed the metastatic nature of the PET/CT-positive coeliac node and showed an incidental B-cell lymphoma in the hepatic pedicle lymph nodes. To the best of our knowledge this is the third case of medullary-like HCC described in the literature, and the first associated to a concomitant typical HCC. Dewey 616.07 Dewey 617 137 Département de pathologie et immunologie 21F 57 Département de chirurgie 222 false 79 Chirurgie viscérale 104 1329 Chirurgie viscérale (HUG) 391 Métastases du foie 657 562 Transplantation et hépatologie 905 Journal of Surgical Case Reports 2018 2 00e5a435-a845-4285-9191-ed4242fdef7f Article (Published version) Public rjy010.pdf 2259958 application/pdf CC BY-NC openAccess Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine clinique / Département de chirurgie

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Medullary-like hepatocellular carcinoma	Journal of Surgical Case Reports			2018	704	209

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Barizzi, Jessica