Changes in interstitial fluid pressure, pericyte coverage and vascular transport induced by low dose photodynamic therapy in malignant pleural mesothelioma

Diplôme Master Changes in interstitial fluid pressure, pericyte coverage and vascular transport induced by low dose photodynamic therapy in malignant pleural mesothelioma eng 2014 author Baldini Greg 659611 director Lange Norbert 135650 director Perentes Jean Yannis director Cavin Sabrina Malignant pleural mesothelioma (MPM) is a devastating disease with a poor prognosis for which a great research effort is currently ongoing to counter tumor resistance to conventional therapy. Solid malignant tumors have an abnormal vasculature, which is characterized by excessive leakiness that ultimately causes tumor interstitial fluid pressure (IFP) to be high. Elevated IFP has been demonstrated to impair fluid convection between the intra- and extra-vascular spaces and to decrease vascular transport. This convection drop is thought to be responsible for bad chemotherapy distribution into tumors leaving areas untreated, which could later be the cause of cancer recurrence. Dewey 615 Travail personnel de recherche, Master en pharmacie 31 Section des sciences pharmaceutiques 17 false 883 Technologie pharmaceutique a2f6f87f-c786-46a6-8230-0b7829494170 Master thesis Restricted TPR-UNIGE__[greg.baldini-12.06.2014-19h18].pdf 2715459 application/pdf restrictedAccess Faculté des sciences / Section des sciences pharmaceutiques

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Changes in interstitial fluid pressure, pericyte coverage and vascular transport induced by low dose photodynamic therapy in malignant pleural mesothelioma				2014	275	8

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Baldini, Greg