Pulmonary Arterial Hypertension among HIV-Infected Children: Results of a National Survey and Review of the Literature

Article Article scientifique Revue de la littérature Pulmonary Arterial Hypertension among HIV-Infected Children: Results of a National Survey and Review of the Literature eng 2015 author L'Huillier Arnaud 0000-0001-9230-7285 543058 author Posfay Barbe Klara 39230 author Pictet Hiba 643844 author Beghetti Maurice 31865 25 10.3389/fped.2015.00025 25905096 2296-2360 Since the advent of highly active anti-retroviral therapy, HIV-related mortality has decreased dramatically. As a consequence, patients are living longer, and HIV infection is becoming a chronic disease. Patients and caretakers have to deal with chronic complications of infection and treatment, such as cardiovascular diseases, which now represent an important health issue, even in the pediatric population. Prevalence of pulmonary arterial hypertension (PAH) in the adult HIV population is around 0.4-0.6%, which is around 1000- to 2500-fold more prevalent than in the general population. In recent adult PAH registries, HIV has been identified as the fourth cause of PAH, accounting for approximately 6-7% of cases. Therefore, regular screening is recommended in HIV-infected adults by many experts. If HIV-associated PAH is mainly reported in HIV-infected adults, pediatric cases have also been, albeit rarely, described. This scarcity may be due to a very low PAH prevalence, or due to the lack of systematic cardiovascular screening in pediatric patients. As PAH may manifest only years or decades after infection, a systematic screening should perhaps also be recommended to HIV-infected children. In this context, we retrospectively looked for PAH screening in children included in our national Swiss Mother and Child HIV cohort study. A questionnaire was sent to all pediatric infectious disease specialists taking care of HIV-infected children in the cohort. The questions tried to identify symptoms suggestive of cardiovascular risk factors and asked which screening test was performed. In the 71 HIV-infected children for which we obtained an answer, no child was known for PAH. However, only two had been screened for PAH, and the diagnosis was not confirmed. In conclusion, PAH in HIV-infected children is possibly underestimated due to lack of screening. Systematic echocardiographic evaluation should be performed in HIV-infected children. Dewey 618 58 Département de pédiatrie, gynécologie et obstétrique 223 false 179 L'hypertension pulmonaire (pédiatrie) 228 515 Recherche en infectiologie pédiatrique et en pédiatrie générale 853 Frontiers in pediatrics 3 b7f6e6fb-12ab-4675-9f4c-8b3b70286d47 Article (Published version) Public 25.pdf 1223758 application/pdf openAccess Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

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Pulmonary Arterial Hypertension among HIV-Infected Children: Results of a National Survey and Review of the Literature	Frontiers in pediatrics			2015	527	338

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