Variable ventilation is equally effective as conventional pressure control ventilation for optimizing lung function in a rabbit model of ARDS

Article Article scientifique Article Variable ventilation is equally effective as conventional pressure control ventilation for optimizing lung function in a rabbit model of ARDS eng 2019 author Fodor Gergely 866229 author Bayat Sam 845411 author Albu Gergely 705225 author Lin Na 597249 author Baudat Aurélie-Djamila 789252 author Danis Judit author Petak Ferenc 133325 author Habre Walid 133724 803 10.3389/fphys.2019.00803 31297064 1664-042X Introducing mathematically derived variability (MVV) into the otherwise monotonous conventional mechanical ventilation has been suggested to improve lung recruitment and gas exchange. Although the application of a ventilation pattern based on variations in physiological breathing (PVV) is beneficial for healthy lungs, its value in the presence of acute respiratory distress syndrome (ARDS) has not been characterized. We therefore aimed at comparing conventional pressure-controlled ventilation with (PCS) or without regular sighs (PCV) to MVV and PVV at two levels of positive end-expiratory pressure (PEEP) in a model of severe ARDS. Dewey 617 Swiss National Science Foundation Experimental and clinical assessments of the benefit of variable ventilation in diseased lungs 169334 CH Project funding 63 Département d'anesthésiologie, pharmacologie, soins intensifs et urgences 229 false 46 Enfants et hyperréactivité bronchique 69 Frontiers in Physiology 10 d74edc62-5791-4e39-b350-dbbb0208308f Article (Published version) Public VV-ARDS.pdf 3096926 application/pdf CC BY 08971e0a-542b-4f9c-8c57-9e99ac707c65 Supplemental data Public Table_1.docx 305093 application/vnd.openxmlformats-officedocument.wordprocessingml.document CC BY openAccess Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences

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Variable ventilation is equally effective as conventional pressure control ventilation for optimizing lung function in a rabbit model of ARDS	Frontiers in Physiology			2019	327	212

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Lin, Na