Action simulation in hallucination-prone adolescents

Article Article scientifique Article Action simulation in hallucination-prone adolescents eng 2013 author Dahoun Tarik 596094 author Eliez Stéphan 0000-0002-8269-3028 39336 author Chen Fei author Badoud Deborah Myriam 635311 author Schneider Maude 0000-0001-7147-8915 594384 author Larøi Frank author Debbané Martin 543333 329 10.3389/fnhum.2013.00329 23847502 1662-5161 Theoretical and empirical accounts suggest that impairments in self-other discrimination processes are likely to promote the expression of hallucinations. Studies using a variety of paradigms involving self-performed actions argue in favor of perspective taking confusion in hallucination-prone subjects. However, our understanding of such processes during adolescence is still at an early stage. The present study thus aims (1) to delineate the neural correlates sustaining mental simulation of actions involving self-performed actions (first-person perspective; 1PP) and other-performed actions (third-person perspective; 3PP) during adolescence (2) to identify atypical activation patterns during 1PP/3PP mental simulation of actions in hallucination-prone adolescents (3) to examine whether differential risk for schizophrenia (clinical vs. genetic) is also associated with differential impairments in the 1PP/3PP mental simulation of actions during adolescence. Twenty-two typically developing controls (Control group; 6 females), 12 hallucination-prone adolescents [auditory hallucination (AH) group; 7 females] and 13 adolescents with 22q11.2 Deletion Syndrome (22q11.2DS group; 4 females) were included in the study. During the fMRI task, subjects were presented with a cue (self-other priming cues) indicating to perform the task using either a first person perspective ("you"-1PP) or a third person perspective ("best friend"-3PP) and then they were asked to mentally simulate actions based on the type of cue. Hallucination-proneness was assessed using a self-report questionnaire [Cardiff Anomalous Perception Scale (CAPS)]. Our results indicated that atypical patterns of cerebral activation, particularly in the key areas of self-other distinction, were found in both groups at risk for auditory hallucinations (AHs and 22q11.2DS). More precisely, adolescents in the AH group presented decreased activations in the right middle occipital gyrus BA19, left cingulate gyrus BA31, and right precuneus BA31 for the 3PP > 1PP contrast. Adolescents in the 22q11.2DS group presented decreased activations in the right superior occipital gyrus BA19, left caudate tail and left precuneus BA7 for the 3PP > 1PP contrast. In comparison to the Control group, only the 22q11.2DS adolescents showed a decreased activation for other-related cues (prime other > prime self contrast) in areas of visual imagery, episodic memory and social cognition. This study characterizes the neural correlates of mental imagery for actions during adolescence, and suggests that a differential risk for hallucination-proneness (clinical vs. genetic) is associated to similar patterns of atypical activations in key areas sustaining self-other discrimination processes. These observations may provide relevant information for future research and prevention strategies with regards to hallucination-proneness during adolescence. 22q11.2 action simulation auditory hallucinations perspective-taking Dewey 150 Dewey 616.8 Dewey 616.89 53 Département de neurosciences fondamentales 21A 60 Département de psychiatrie 225 108 Section de psychologie 71 false 421 Laboratoire d'imagerie et de psychopathologie développementale 693 53 Plasticité des synapses excitatrices 76 603 Unité de psychologie clinique développementale(UPCD) Frontiers in human neuroscience 7 59f74bae-3055-4978-a575-c9913191884b Article (Published version) Public Dahoun2013_Frontiers.pdf 2064288 application/pdf openAccess Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales Faculté de médecine / Section de médecine clinique / Département de psychiatrie Faculté de psychologie et des sciences de l'éducation / Section de psychologie

Title	Published in	Year	Views	Downloads

Simulation d'action et risque hallucinatoire à l'adolescence		2014	798	27
Action simulation in hallucination-prone adolescents	Frontiers in human neuroscience	2013	772	424

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Dahoun, Tarik