Ocular biocompatibility of a poly(ortho ester) characterized by autocatalyzed degradation

Article Article scientifique Article Ocular biocompatibility of a poly(ortho ester) characterized by autocatalyzed degradation eng 2003-09-04 author Einmahl Suzanne 87542 author Ponsart Stéphanie 134385 author Bejjani Riad Antoine 561686 author D'Hermies François author Savoldelli Michelle author Heller Jorge author Tabatabay Cyrus A. 28691 author Gurny Robert 24779 author Behar-Cohen Francine 44-53 10.1002/jbm.a.10597 1549-3296 The biocompatibility of autocatalyzed poly(ortho ester) (POE70LA30), a viscous, hydrophobic, bioerodible polymer, was investigated. POE70LA30 was synthesized, sterilized by gamma irradiation, and injected in rabbit eyes at adequate volumes through subconjunctival, intracameral, intravitreal, and suprachoroidal routes. Clinical examinations were performed postoperatively at regular time points for 6 mo, and histopathologic analysis was carried out to confirm tissular biocompatibility. After subconjunctival injection, the polymer was well tolerated and persisted in the subconjunctival space for about 5 weeks. In the case of intracameral injections, polymer biocompatibility was good; the POE70LA30 bubble was still present in the anterior chamber for up to 6 mo after injection. No major histopathologic anomalies were detected, with the exception of a localized Descemet membrane thickening. After intravitreal administration, POE70LA30 biocompatibility was excellent, and no inflammatory reaction could be detected during the observation period. The polymer was degraded in approximately 3 mo. Suprachoroidal injections of POE70LA30 were reproducible and well tolerated. POE70LA30 triggered a slight elevation of the retina and choroid upon clinical observation. The polymer was detectable in the suprachoroidal space for about 6 mo. No inflammatory reaction and no major retinal anomalies could be detected by histology. In conclusion, POE70LA30 appears to be a promising biomaterial for intraocular application, potentially providing sustained drug delivery over an extended period of time, with a good tolerance. Biocompatibility Poly(ortho esters) Biodegradable polymers Ocular Rabbit Drug delivery Biomaterials Dewey 615 31 Section des sciences pharmaceutiques 17 false Journal of biomedical materials research. Part A 67 1 46ed0c2f-09eb-4a92-91bb-12acba95a5fe Article (Published version) Restricted EINMAHL_JBMR_200253.pdf 443672 application/pdf restrictedAccess Faculté des sciences / Section des sciences pharmaceutiques

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Ocular biocompatibility of a poly(ortho ester) characterized by autocatalyzed degradation	Journal of biomedical materials research. Part A			2003	195	0

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Bejjani, Riad Antoine