Hippocampal volume reduction in chromosome 22q11.2 deletion syndrome (22q11.2DS): a longitudinal study of morphometry and symptomatology

Article Article scientifique Article Hippocampal volume reduction in chromosome 22q11.2 deletion syndrome (22q11.2DS): a longitudinal study of morphometry and symptomatology eng 2012 author Flahault Astrid 540852 author Schaer Marie 0000-0001-8479-6365 510515 author Ottet Marie-Christine 583537 author Debbané Martin 543333 author Eliez Stéphan 39336 1-5 10.1016/j.pscychresns.2011.09.003 22920836 0165-1781 Recent studies observed an association between the structural integrity of the hippocampal structure and the manifestations of clinically significant psychotic symptoms in participants at high risk for psychosis. The present study sought to investigate the longitudinal trajectory of the hippocampal volume and its subregions among a sample of participants affected by 22q11.2 deletion syndrome (22q11.2DS), a neurogenetic disorder associated with elevated risk for psychosis. We specifically investigated possible correlations between hippocampal volumes, as measured by magnetic resonance imaging (MRI), and the manifestation of positive psychotic symptoms (hallucinations and delusions). Regional hippocampal volumes were measured twice with cerebral MRI obtained at 3-year intervals in 30 healthy participants and 31 gender-matched 22q11.2 microdeletion carriers aged 6 to 22. We examined potential associations between psychotic symptom manifestations and volumetric parameters at both time points. We found a hippocampal body-driven significant reduction in hippocampal volume among patients with 22q11DS compared to controls. No significant group by time interaction for the total or the subregional volumes were observed. In patients, larger hippocampal head at baseline was associated with the presence of hallucinations at follow-up. We first discuss the reduced hippocampal body finding in light of potentially abnormal mesiocortical circuits. We further discuss the association between baseline hippocampal head volume in participants with 22q11DS as a possible marker related to the later unfolding of psychotic symptoms. Adolescent Adult Case-Control Studies Catechol O-Methyltransferase/genetics Child Delusions/etiology/pathology DiGeorge Syndrome/complications/pathology/psychology Female Hallucinations/etiology/pathology Hippocampus/pathology/physiopathology Humans Longitudinal Studies Magnetic Resonance Imaging Male Neuroimaging Organ Size Psychotic Disorders/etiology/pathology Dewey 150 Dewey 616.89 60 Département de psychiatrie 225 108 Section de psychologie 71 false 421 Laboratoire d'imagerie et de psychopathologie développementale 693 603 Unité de psychologie clinique de l'adolescence (UPCA) Psychiatry research 203 1 abcfbd75-da1b-4b46-b4d2-b0420af8511f Article (Published version) Public Flahault2012_Psy_Res.pdf 281836 application/pdf openAccess Faculté de médecine / Section de médecine clinique / Département de psychiatrie Faculté de psychologie et des sciences de l'éducation / Section de psychologie

Title	Published in	Year	Views	Downloads

Hippocampal volume reduction in chromosome 22q11.2 deletion syndrome (22q11.2DS): a longitudinal study of morphometry and symptomatology	Psychiatry research	2012	786	618
Imagerie cérébrale structurelle dans la microdélétion 22q11.2 : étude longitudinale des volumes hippocampiques et leurs liens avec l'apparition des symptômes psychotiques		2012	739	718

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Flahault, Astrid