Low-dose sufentanil does not potentiate intrathecal morphine for perioperative analgesia after major colorectal surgery

Article Article scientifique Article Low-dose sufentanil does not potentiate intrathecal morphine for perioperative analgesia after major colorectal surgery eng 2007 author Culebras Javier 519663 author Savoldelli Georges Louis 0000-0002-8968-6920 41344 author Van Gessel Elisabeth 27960 author Klopfenstein Claude-Eric 549885 author Saudan Frei Sonja 549904 author Schiffer Eduardo 0000-0002-7415-4315 33705 811-817 10.1007/BF03021708 17934162 0832-610X Both intrathecal sufentanil (ITS) and intrathecal morphine (ITM) improve analgesia in obstetrical or cardiac procedures. From a pharmacokinetic standpoint, combining these two opioids may improve perioperative analgesia. We performed a prospective randomized double-blind study to compare the analgesic efficacy of ITM alone vs a mixture of a low dose of ITS plus ITM for perioperative pain relief in colorectal surgery. Adolescent Adult Aged Aged, 80 and over Analgesia, Patient-Controlled Analgesics, Opioid/adverse effects/therapeutic use Colon/surgery Double-Blind Method Drug Interactions Female Humans Infusions, Intravenous Male Middle Aged Morphine/adverse effects/therapeutic use Pain, Postoperative/drug therapy Patient Satisfaction Postoperative Care Prospective Studies Rectum/surgery Sufentanil/adverse effects/therapeutic use Dewey 610/370 Dewey 617 Dewey 618 Open Access - Licence nationale Springer 48 Unité de développement et de recherche en éducation médicale 204 58 Département de pédiatrie, gynécologie et obstétrique 223 63 Département d'anesthésiologie, pharmacologie, soins intensifs et urgences 229 false 46 Enfants et hyperréactivité bronchique 69 538 Formation et développement professionnel 878 Canadian journal of anaesthesia 54 10 7fa1aff3-6bb8-498a-8299-e97cdc07a61c Article (Published version) Public 811-817.pdf 887942 application/pdf openAccess Faculté de médecine / Unité de développement et de recherche en éducation médicale Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences

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Low-dose sufentanil does not potentiate intrathecal morphine for perioperative analgesia after major colorectal surgery	Canadian journal of anaesthesia			2007	653	175

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Culebras, Javier