Using the Tissue Impulse Response Function to Streamline Fractionated MRgFUS-Induced Hyperthermia

Article Article scientifique Article Using the Tissue Impulse Response Function to Streamline Fractionated MRgFUS-Induced Hyperthermia eng 2025-02-04 author Guillemin Pauline Coralie 0000-0003-2792-6543 Image Guided Interventions Laboratory, GR-949, Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland. 877140 Département de radiologie et informatique médicale (RADIO) author M'Rad Yacine 0000-0003-3295-3386 Image Guided Interventions Laboratory, GR-949, Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland. 895739 author Dipasquale Giovanna 0000-0002-9225-9559 Herosupport SA, Route de l'Uche 53, 1255 Veyrier, Switzerland. author Lorton Orane 0000-0002-6500-1093 Image Guided Interventions Laboratory, GR-949, Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland.,Clinical Neurosciences Department, University Hospitals of Geneva, Rue Gabrielle-Perret-Gentil 4, 1205 Geneva, Switzerland. 855324 author Fleury Vanessa Clinical Neurosciences Department, University Hospitals of Geneva, Rue Gabrielle-Perret-Gentil 4, 1205 Geneva, Switzerland.,Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland. 840771 Département des neurosciences cliniques (OTONO) author Momjian Shahan Marc Clinical Neurosciences Department, University Hospitals of Geneva, Rue Gabrielle-Perret-Gentil 4, 1205 Geneva, Switzerland.,Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland. 84022 Département des neurosciences cliniques (OTONO) author Borich Anna Image Guided Interventions Laboratory, GR-949, Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland. 430111 Département de radiologie et informatique médicale (RADIO) author Crowe Lindsey A 0000-0002-2044-1220 Radiation Oncology, Oncology Institute of Southern Switzerland (IOSI), EOC, 6500 Bellinzona, Switzerland. author Zilli Thomas 0000-0002-4784-9883 Image Guided Interventions Laboratory, GR-949, Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland.,Radiation Oncology, Oncology Institute of Southern Switzerland (IOSI), EOC, 6500 Bellinzona, Switzerland.,Faculty of Biomedical Sciences, Università della Svizzera Italiana, 6900 Lugano, Switzerland. 791833 Département de radiologie et informatique médicale (RADIO) author Boudabbous Sana 0000-0003-0516-4613 Image Guided Interventions Laboratory, GR-949, Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland.,Radiology Division, HUG, University Hospitals of Geneva, Rue Gabrielle-Perret-Gentil 4, 1205 Geneva, Switzerland. 800627 Département de radiologie et informatique médicale (RADIO) author Salomir Rares Vincent 0000-0002-4182-0959 Image Guided Interventions Laboratory, GR-949, Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland.,Radiology Division, HUG, University Hospitals of Geneva, Rue Gabrielle-Perret-Gentil 4, 1205 Geneva, Switzerland. 682178 Département de radiologie et informatique médicale (RADIO) 515 10.3390/cancers17030515 39941882 2072-6694 PMC11817472 https://www.mdpi.com/2072-6694/17/3/515 Background/Objectives : Combining radiation therapy with mild hyperthermia, especially via magnetic resonance-guided focused ultrasound (MRgFUS), holds promise for enhancing tumor control and alleviating symptoms in cancer patients. However, current clinical applications of MRgFUS focus primarily on ablative treatments, and using MRI guidance for each radiation session increases treatment costs and logistical demands. This study aimed to test a streamlined workflow for repeated hyperthermia treatments that reduces the need for continuous MRI monitoring, using an approach based on impulse response function (Green's function) to optimize acoustic power settings in advance. Methods : We implemented the Green's function approach in a perfused, tissue-mimicking phantom, conducting 30 experiments to simulate hyperthermia delivery via MRgFUS. Pre-calculated acoustic power settings were applied to maintain a stable hyperthermia target without the need for real-time feedback control from MRI thermometry. Additionally, a retrospective analysis of patient thermometry data from MRgFUS sonications was performed to assess feasibility in clinical contexts. Results : Our experiments demonstrated consistent, stable hyperthermia (+7 °C) for 15 min across varying perfusion rates, outperforming conventional closed-loop MRI feedback methods in maintaining temperature stability. The retrospective analysis confirmed that this method is noise-robust and clinically applicable. Conclusions : This off-line approach to hyperthermia control could simplify the integration of MRgFUS hyperthermia in cancer treatment, reducing costs and logistical barriers. These findings suggest that our method may enable the broader adoption of hyperthermia in radiation therapy, supporting its role as a viable adjuvant treatment in oncology. HIFU MRI Hyperthermia therapy Dewey 616.8 Dewey 616.0757 Swiss Innovation Agency 103.638 IP-LS 61 Département des neurosciences cliniques 226 62 Département de radiologie et informatique médicale 227 false 926 Imagerie per-opératoire multi-modalité en radiologie interventionnelle 949 https://yareta.unige.ch/archives/cde392ef-6904-40f5-9246-a2b9cd93f36c Cancers 17 3 e1ea598e-f157-4902-9404-1596eca6d3ac Article (Published version) Public Guillemin_2025.pdf 8079418 application/pdf CC BY-4.0 da8c79086f391c0789c879ac48e2388a52051b628fcf6789369be5e494857839 openAccess Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale

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Using the Tissue Impulse Response Function to Streamline Fractionated MRgFUS-Induced Hyperthermia	Cancers			2025	17	59

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