Understanding the Impact of Polyunsaturated Fatty Acids on Age-Related Macular Degeneration: A Review

Article Article scientifique Revue de la littérature Understanding the Impact of Polyunsaturated Fatty Acids on Age-Related Macular Degeneration: A Review eng 2024-04-07 2024-04-07 author Brito Maëlis Unither Développement Bordeaux, Avenue Toussaint Catros, 33185 Le Haillan, France.,Université Paris Cité, CNRS, INSERM, UTCBS, Unité de Technologies Chimiques et Biologiques pour la Santé, F-75006 Paris, France.,Département de Recherche et Développement (DRDP), Agence Générale des Equipements et Produits de Santé (AGEPS), Assistance Publique Hôpitaux de Paris (AP-HP), 7 Rue du Fer-à-Moulin, 75005 Paris, France.,Institute of Pharmaceutical Sciences of Western Switzerland (ISPSO), School of Pharmaceutical Sciences, University of Geneva, Rue Michel-Servet 1, 1206 Geneva, Switzerland. 402685 author Sorbier Capucine Unither Développement Bordeaux, Avenue Toussaint Catros, 33185 Le Haillan, France. author Mignet Nathalie 0000-0002-3323-2997 Université Paris Cité, CNRS, INSERM, UTCBS, Unité de Technologies Chimiques et Biologiques pour la Santé, F-75006 Paris, France. author Boudy Vincent 0000-0002-9811-1520 Université Paris Cité, CNRS, INSERM, UTCBS, Unité de Technologies Chimiques et Biologiques pour la Santé, F-75006 Paris, France.,Département de Recherche et Développement (DRDP), Agence Générale des Equipements et Produits de Santé (AGEPS), Assistance Publique Hôpitaux de Paris (AP-HP), 7 Rue du Fer-à-Moulin, 75005 Paris, France. author Borchard Gerrit 0000-0001-6268-2586 Institute of Pharmaceutical Sciences of Western Switzerland (ISPSO), School of Pharmaceutical Sciences, University of Geneva, Rue Michel-Servet 1, 1206 Geneva, Switzerland. 635281 Section des sciences pharmaceutiques (FARMA) author Vacher Gaëlle 0000-0003-0307-1990 Institute of Pharmaceutical Sciences of Western Switzerland (ISPSO), School of Pharmaceutical Sciences, University of Geneva, Rue Michel-Servet 1, 1206 Geneva, Switzerland. 672085 4099 10.3390/ijms25074099 38612907 1422-0067 PMC11012607 https://www.mdpi.com/1422-0067/25/7/4099 <p>Age-related Macular Degeneration (AMD) is a multifactorial ocular pathology that destroys the photoreceptors of the macula. Two forms are distinguished, dry and wet AMD, with different pathophysiological mechanisms. Although treatments were shown to be effective in wet AMD, they remain a heavy burden for patients and caregivers, resulting in a lack of patient compliance. For dry AMD, no real effective treatment is available in Europe. It is, therefore, essential to look for new approaches. Recently, the use of long-chain and very long-chain polyunsaturated fatty acids was identified as an interesting new therapeutic alternative. Indeed, the levels of these fatty acids, core components of photoreceptors, are significantly decreased in AMD patients. To better understand this pathology and to evaluate the efficacy of various molecules, in vitro and in vivo models reproducing the mechanisms of both types of AMD were developed. This article reviews the anatomy and the physiological aging of the retina and summarizes the clinical aspects, pathophysiological mechanisms of AMD and potential treatment strategies. In vitro and in vivo models of AMD are also presented. Finally, this manuscript focuses on the application of omega-3 fatty acids for the prevention and treatment of both types of AMD.</p> AMD in vitro models AMD in vivo models Age-related macular degeneration (AMD) Omega-3 fatty acids Photoreceptors Polyunsaturated fatty acids (PUFA) Retina Dewey 615 31 Section des sciences pharmaceutiques 17 false International journal of molecular sciences 25 7 2abc38a6-327c-48cc-a674-aac32e95b47d Article (Published version) Public Article_scientifique_from_crossref.pdf 2241296 application/pdf CC BY-4.0 dd948b928c0e84c0d95cbecce6ba904652546a9b36f0fb5045d8b6aa26bb84ec openAccess Faculté des sciences / Section des sciences pharmaceutiques

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Understanding the Impact of Polyunsaturated Fatty Acids on Age-Related Macular Degeneration: A Review	International journal of molecular sciences			2024	44	17

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Brito, Maëlis