Time course of appearance of markers of arrhythmia in patients with tetralogy of Fallot before and after surgery

Article Article scientifique Article Time course of appearance of markers of arrhythmia in patients with tetralogy of Fallot before and after surgery eng 2004 author Al Balkhie Rim 100458 author Beghetti Maurice 31865 author Friedli Beat 25332 360-366 10.1017/S1047951104004020 15680040 1047-9511 Sudden death and ventricular tachycardia are known to occur late after correction of tetralogy of Fallot. Abnormal dispersion of the QT interval, ventricular late potentials, and prolongation of the QRS complex, alone or in combination, are useful markers of the risk for such complications. Our present prospective study investigates the time course of appearance of two markers, dispersion of QT and JT, and ventricular late potentials, before and after corrective surgery. Dispersion of QT and JT, and signal averaged electrocardiographic parameters, were determined sequentially in 20 patients before, a mean of 9 +/- 3 days after, and again 35 +/- 11 days post-operatively. Dispersion of QT was already abnormal before surgery in two-fifths of the patients, but increased markedly in the later post-operative period. Ventricular late potentials were absent before surgery and in the immediate post-operative period, but were found in one-fifth of patients 1 month later. We conclude that abnormal dispersion of QT is, to some extent, a fact of the natural history of tetralogy of Fallot, but is significantly amplified by surgery. Ventricular late potentials, on the other hand, are absent before surgery, but appear with some delay after the operation, probably as a result of scarring rather than the surgical incision itself. Long-term follow-up is needed to assess the significance of these findings. Adolescent Cardiac Surgical Procedures/adverse effects/methods Child Child, Preschool Death, Sudden, Cardiac/etiology Electrocardiography Female Follow-Up Studies Heart Conduction System/physiopathology Humans Male Postoperative Period Preoperative Care/methods Prospective Studies Risk Assessment Severity of Illness Index Tachycardia, Ventricular/diagnosis/etiology/mortality Tetralogy of Fallot/complications/diagnosis/surgery Time Factors Dewey 618 58 Département de pédiatrie, gynécologie et obstétrique 223 false 179 L'hypertension pulmonaire (pédiatrie) 228 Cardiology in the young 14 4 0da53c7e-dc92-436b-b095-a77031d7525a Article (Published version) Restricted 360-366.pdf 1130795 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

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Time course of appearance of markers of arrhythmia in patients with tetralogy of Fallot before and after surgery	Cardiology in the young			2004	528	0

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Al Balkhie, Rim