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Principles of proportional recovery after stroke generalize to neglect and aphasia

Published in European Journal of Neurology. 2017, vol. 24, no. 8, p. 1084-1087
Abstract BACKGROUND AND PURPOSE: Motor recovery after stroke can be characterized into two different patterns. A majority of patients recover about 70% of initial impairment, whereas some patients with severe initial deficits show little or no improvement. Here, we investigated whether recovery from visuospatial neglect and aphasia is also separated into two different groups and whether similar proportions of recovery can be expected for the two cognitive functions. METHODS: We assessed 35 patients with neglect and 14 patients with aphasia at 3 weeks and 3 months after stroke using standardized tests. Recovery patterns were classified with hierarchical clustering and the proportion of recovery was estimated from initial impairment using a linear regression analysis. RESULTS: Patients were reliably clustered into two different groups. For patients in the first cluster (n = 40), recovery followed a linear model where improvement was proportional to initial impairment and achieved 71% of maximal possible recovery for both cognitive deficits. Patients in the second cluster (n = 9) exhibited poor recovery (<25% of initial impairment). CONCLUSIONS: Our findings indicate that improvement from neglect or aphasia after stroke shows the same dichotomy and proportionality as observed in motor recovery. This is suggestive of common underlying principles of plasticity, which apply to motor and cognitive functions.
PMID: 28585297
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Research groups Neuroréhabilitation assistée par imagerie (910)
Lésions cérébrales et attention spatiale (705)
Amnésie (289)
FNS: 320030-146639
FNS: 320030-152689
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MARCHI, Nicola et al. Principles of proportional recovery after stroke generalize to neglect and aphasia. In: European Journal of Neurology, 2017, vol. 24, n° 8, p. 1084-1087. doi: 10.1111/ene.13296 https://archive-ouverte.unige.ch/unige:99811

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Deposited on : 2017-11-29

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