Insulin modulation of luteinizing hormone secretion in normal female volunteers and lean polycystic ovary syndrome patients

Moret Bochatay, Mallory; Stettler, Rodrigue; Rodieux, Frédérique; Gaillard, Rolf Christian; Waeber, Gérard; Wirthner, Daniel; Giusti, Vittorio; Tappy, Luc; Pralong, François Pierre

doi:10.1159/000160911

Scientific article

English

Insulin modulation of luteinizing hormone secretion in normal female volunteers and lean polycystic ovary syndrome patients

ContributorsMoret Bochatay, Mallory; Stettler, Rodrigue; Rodieux, Frédérique; Gaillard, Rolf Christian; Waeber, Gérard; Wirthner, Daniel; Giusti, Vittorio; Tappy, Luc; Pralong, François Pierre

Published inNeuroendocrinology, vol. 89, no. 2, p. 131-139

Publication date2009

Abstract

Endocrine features of polycystic ovary syndrome (PCOS) include altered ovarian steroidogenesis, hyperinsulinemia and abnormal luteinizing hormone (LH) secretion. This study was undertaken to further evaluate the role of insulin to modulate LH secretion in lean PCOS patients with normal insulin sensitivity and normal volunteers.

Keywords

Adult
Female
Glucose Clamp Technique
Gonadotropin-Releasing Hormone/metabolism
Humans
Hypothalamus/metabolism
Insulin/administration & dosage/blood/pharmacology
Luteinizing Hormone/blood/drug effects/secretion
Polycystic Ovary Syndrome/metabolism
Thinness

Affiliation

Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences

Research group

Groupe Desmeules Jules (pharmacologie/toxicologie) (567)

Citation (ISO format)

MORET BOCHATAY, Mallory et al. Insulin modulation of luteinizing hormone secretion in normal female volunteers and lean polycystic ovary syndrome patients. In: Neuroendocrinology, 2009, vol. 89, n° 2, p. 131–139. doi: 10.1159/000160911

Article (Published version)

Identifiers

PID : unige:99806
DOI : 10.1159/000160911
PMID : 18832802

ISSN of the journal0028-3835

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Insulin modulation of luteinizing hormone secretion in normal female volunteers and lean polycystic ovary syndrome patients

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