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Insulin modulation of luteinizing hormone secretion in normal female volunteers and lean polycystic ovary syndrome patients

ContributorsMoret Bochatay, Mallory; Stettler, Rodrigue; Rodieux, Frédérique; Gaillard, Rolf Christian; Waeber, Gérard; Wirthner, Daniel; Giusti, Vittorio; Tappy, Luc; Pralong, François Pierre
Published inNeuroendocrinology, vol. 89, no. 2, p. 131-139
Publication date2009
Abstract

Endocrine features of polycystic ovary syndrome (PCOS) include altered ovarian steroidogenesis, hyperinsulinemia and abnormal luteinizing hormone (LH) secretion. This study was undertaken to further evaluate the role of insulin to modulate LH secretion in lean PCOS patients with normal insulin sensitivity and normal volunteers.

Keywords
  • Adult
  • Female
  • Glucose Clamp Technique
  • Gonadotropin-Releasing Hormone/metabolism
  • Humans
  • Hypothalamus/metabolism
  • Insulin/administration & dosage/blood/pharmacology
  • Luteinizing Hormone/blood/drug effects/secretion
  • Polycystic Ovary Syndrome/metabolism
  • Thinness
Affiliation entities
Research groups
Citation (ISO format)
MORET BOCHATAY, Mallory et al. Insulin modulation of luteinizing hormone secretion in normal female volunteers and lean polycystic ovary syndrome patients. In: Neuroendocrinology, 2009, vol. 89, n° 2, p. 131–139. doi: 10.1159/000160911
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Article (Published version)
accessLevelRestricted
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ISSN of the journal0028-3835
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