Role of Gag mutations in PI resistance in the Swiss HIV cohort study: bystanders or contributors?

Kletenkov, K; Hoffmann, D; Böni, J; Yerly Ferrillo, Sabine; Aubert, Vincent; Schöni-Affolter, F; Struck, D; Verheyen, J; Klimkait, T

doi:10.1093/jac/dkw493

Scientific article

English

Role of Gag mutations in PI resistance in the Swiss HIV cohort study: bystanders or contributors?

ContributorsKletenkov, K; Hoffmann, D; Böni, J; Yerly Ferrillo, Sabine; Aubert, Vincent; Schöni-Affolter, F; Struck, D; Verheyen, J; Klimkait, T

Published inJournal of Antimicrobial Chemotherapy, vol. 72, no. 3, p. 866-875

Publication date2017

Abstract

HIV Gag mutations have been reported to confer PI drug resistance. However, clinical implications are still controversial and most current genotyping algorithms consider solely the protease gene for assessing PI resistance.

Keywords

Cohort Studies
Drug Resistance
Viral/genetics
Genes
Gag
Genotype
HIV Infections/blood/drug therapy/virology
HIV Protease/genetics
HIV Protease Inhibitors/pharmacology/therapeutic use
HIV-1/drug effects/genetics
Humans
Mutation
Missense
Prevalence
RNA
Viral/blood
Sequence Analysis
DNA
Switzerland
Treatment Failure
Gag Gene Products
Human Immunodeficiency Virus/genetics

Affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie

Research groups

Virologie clinique (668)

Citation (ISO format)

KLETENKOV, K et al. Role of Gag mutations in PI resistance in the Swiss HIV cohort study: bystanders or contributors? In: Journal of Antimicrobial Chemotherapy, 2017, vol. 72, n° 3, p. 866–875. doi: 10.1093/jac/dkw493

Article (Published version)

Identifiers

PID : unige:99804
DOI : 10.1093/jac/dkw493
PMID : 27999036

Journal ISSN0305-7453

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Update09/02/2026 15:33:48

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Role of Gag mutations in PI resistance in the Swiss HIV cohort study: bystanders or contributors?

HIV Gag mutations have been reported to confer PI drug resistance. However, clinical implications are still controversial and most current genotyping algorithms consider solely the protease gene for assessing PI resistance.

Technical informations