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Role of Gag mutations in PI resistance in the Swiss HIV cohort study: bystanders or contributors?

Kletenkov, K
Hoffmann, D
Böni, J
Schöni-Affolter, F
Struck, D
Verheyen, J
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Published in The Journal of antimicrobial chemotherapy. 2017, vol. 72, no. 3, p. 866-875
Abstract HIV Gag mutations have been reported to confer PI drug resistance. However, clinical implications are still controversial and most current genotyping algorithms consider solely the protease gene for assessing PI resistance.
Keywords Cohort StudiesDrug ResistanceViral/geneticsGenesGagGenotypeHIV Infections/blood/drug therapy/virologyHIV Protease/geneticsHIV Protease Inhibitors/pharmacology/therapeutic useHIV-1/drug effects/geneticsHumansMutationMissensePrevalenceRNAViral/bloodSequence AnalysisDNASwitzerlandTreatment FailureGag Gene ProductsHuman Immunodeficiency Virus/genetics
PMID: 27999036
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Research group Groupe Laurent Kaiser (virologie clinique) (668)
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KLETENKOV, K et al. Role of Gag mutations in PI resistance in the Swiss HIV cohort study: bystanders or contributors?. In: Journal of Antimicrobial Chemotherapy, 2017, vol. 72, n° 3, p. 866-875. doi: 10.1093/jac/dkw493 https://archive-ouverte.unige.ch/unige:99804

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Deposited on : 2017-11-29

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