Scientific article

Targeted Isolation of Monoterpene Indole Alkaloids from Palicourea sessilis

Published inJournal of Natural Products, vol. 80, no. 11, p. 3032-3037
Publication date2017

Phytochemical investigation of the alkaloid extract of Palicourea sessilis by LC-HRMS/MS using molecular networking and an in silico MS/MS fragmentation approach suggested the presence of several new monoterpene indole alkaloids. These compounds were isolated by semipreparative HPLC, and their structures confirmed by means of HRMS, NMR, and ECD measurements as 4-N-methyllyaloside (3), 4-N-methyl-3,4-dehydrostrictosidine (4), 4β-hydroxyisodolichantoside (6), and 4α-hydroxyisodolichantoside (7), as well as the known alkaloids alline (1), N-methyltryptamine (2), isodolichantoside (5), and 5-oxodolichantoside (8). In addition, the acetylcholinesterase inhibitory activity of the compounds was evaluated up to 50 μM.

Citation (ISO format)
KLEIN-JÚNIOR, Luiz C. et al. Targeted Isolation of Monoterpene Indole Alkaloids from <i>Palicourea sessilis</i>. In: Journal of Natural Products, 2017, vol. 80, n° 11, p. 3032–3037. doi: 10.1021/acs.jnatprod.7b00681
Main files (1)
Article (Published version)
ISSN of the journal0163-3864

Technical informations

Creation11/23/2017 12:04:00 PM
First validation11/23/2017 12:04:00 PM
Update time03/15/2023 2:28:53 AM
Status update03/15/2023 2:28:52 AM
Last indexation10/19/2023 7:18:36 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack