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English

Association of postoperative delirium with markers of neurodegeneration and brain amyloidosis: a pilot study

Contributors

Rolandi, Elena; Cavedo, Enrica; Pievani, Michela; Galluzzi, Samantha; Ribaldi, Federica; Buckley, Christopher; Cunningham, Colm; Guerra, Ugo Paolo; Musarra, Monica; Morzenti, Sabrina; Magnaldi, Silvia; Patassini, Mirko; Terragnoli, Flavio; Matascioli, Luca; Franzoni, Simone; Annoni, Giorgio; Carnevali, Lucio; Bellelli, Giuseppe; Frisoni, Giovanni

Published in

Neurobiology of Aging, vol. 61, p. 93-101

Publication date

2017

Abstract

The aim of the study was to investigate the association between postoperative delirium (POD) and in vivo markers of Alzheimer's disease pathology in nondemented hip fracture surgery patients. POD was assessed with the Confusion Assessment Method. Amyloid load was quantified on (18)F-Flutemetamol positron emission tomography images as standardized uptake value ratio. Secondary outcome measures were gray matter volumes, white matter integrity, and functional connectivity at rest. All the patients with POD (POD+, N = 5) were amyloid negative (standardized uptake value ratio <0.59), whereas 6 out of 11 patients without POD (POD-) showed brain amyloid positivity. POD+ compared to POD- displayed: lower gray matter volumes in the amygdala (p = 0.003), in the middle temporal gyrus and in the anterior cingulate cortex (p < 0.001), increased diffusivity in the genu of the corpus callosum and in the anterior corona radiata (p < 0.05), and higher functional connectivity within the default mode network (p < 0.001). POD patients showed altered gray and white matter integrity in the fronto-limbic regions in absence of brain amyloidosis. Based on this preliminary investigation, delirium pathophysiology might be independent of Alzheimer's disease. Future studies on larger samples are needed to confirm this hypothesis.

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

ROLANDI, Elena et al. Association of postoperative delirium with markers of neurodegeneration and brain amyloidosis: a pilot study. In: Neurobiology of Aging, 2017, vol. 61, p. 93–101. doi: 10.1016/j.neurobiolaging.2017.09.020

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

0197-4580
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Technical informations

Creation

09/11/2017 10:27:00

First validation

09/11/2017 10:27:00

Update

15/03/2023 02:28:17

Status update

15/03/2023 02:28:16

Last indexation

31/10/2024 08:48:27
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