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Title

Cerebral PET glucose hypometabolism in subjects with mild cognitive impairment and higher EEG high-alpha/low-alpha frequency power ratio

Authors
Moretti, Davide Vito
Pievani, Michela
Pini, Lorenzo
Guerra, Ugo Paolo
Paghera, Barbara
Published in Neurobiology of Aging. 2017, vol. 58, p. 213-224
Abstract In Alzheimer's disease (AD) research, both 2-deoxy-2-((18)F)fluoro-D-glucose (FDG) positron emission tomography (PET) and electroencephalography (EEG) are reliable investigational modalities. The aim of this study was to investigate the associations between EEG High-alpha/Low-alpha (H-alpha/L-alpha) power ratio and cortical glucose metabolism. A total of 23 subjects with mild cognitive impairment (MCI) underwent FDG-PET and EEG examinations. H-alpha/L-alpha power ratio was computed for each subject and 2 groups were obtained based on the increase of the power ratio. The subjects with higher H-alpha/L-alpha power ratio showed a decrease in glucose metabolism in the hub brain areas previously identified as typically affected by AD pathology. In subjects with higher H-alpha/L-alpha ratio and lower metabolism, a "double alpha peak" was identified in the EEG spectrum and a U-shaped correlation between glucose metabolism and increase of H-alpha/L-alpha power ratio has been found. Moreover, in this group, a conversion rate of 62.5% at 24 months was detected, significantly different from the chance percentage expected. The neurophysiological meaning of the interplay between alpha oscillations and glucose metabolism and the possible interest of the H-alpha/L-alpha power ratio as a clinical biomarker in AD have been discussed.
Identifiers
PMID: 28755648
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Research group Troubles de mémoire et maladie d'Alzeimer (935)
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MORETTI, Davide Vito et al. Cerebral PET glucose hypometabolism in subjects with mild cognitive impairment and higher EEG high-alpha/low-alpha frequency power ratio. In: Neurobiology of Aging, 2017, vol. 58, p. 213-224. https://archive-ouverte.unige.ch/unige:99656

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Deposited on : 2017-11-24

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