UNIGE document Scientific Article
previous document  unige:99636  next document
add to browser collection

Paraneoplastic mucous membrane pemphigoid with ocular and laryngeal involvement

Published in BMJ case reports. 2017, vol. 2017
Abstract A 73-year-old woman was treated 8 years previously for synchronous breast and uterine neoplasms. She presented with a severe sore throat, odynophagia, dysphonia, dyspnoea, ocular irritation and weight loss over the last 3 months. Physical examination revealed ulcerations in the oral cavity, posterior pharyngeal wall and supraglottic larynx, nasal crusting, bilateral conjunctivitis and three cutaneous blisters. A diagnosis of anti-laminin 5 mucous membrane pemphigoid was retained, based on skin biopsy, direct immunofluorescence and immunoprecipitation. A positron emission tomography (PET)-CT detected multiple adenopathies. Cytology revealed adenocarcinoma with an immunocytology compatible with a breast origin and this was considered as a late metastatic recurrence of her previous breast cancer. A treatment of prednisone, dapsone and hormonotherapy was introduced, but intravenous immunoglobulin and rituximab were added due to new mucosal lesions. Despite treatment, a posterior laryngeal scar and bilateral symblepharon were developed. After 3 years, the patient is still alive and reports a satisfactory quality of life.
PMID: 28801511
Full text
Article (Published version) (1.6 MB) - public document Free access
Research group Groupe Dulguerov Pavel (ORL et chirurgie cervico-faciale) (145)
(ISO format)
LAMBIEL, Silvia et al. Paraneoplastic mucous membrane pemphigoid with ocular and laryngeal involvement. In: BMJ Case Reports, 2017, vol. 2017. doi: 10.1136/bcr-2017-220887 https://archive-ouverte.unige.ch/unige:99636

355 hits



Deposited on : 2017-11-24

Export document
Format :
Citation style :