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Ocular drug delivery targeting the retina and retinal pigment epithelium using polylactide nanoparticles

ContributorsBourges, Jean-Louis; Gautier, Sandrine E; Delie Salmon, Florence; Bejjani, Riad A; Jeanny, Jean-Claude; Gurny, Robert; BenEzra, David; Behar-Cohen, Francine F
Published inInvestigative Ophthalmology & Visual Science, vol. 44, no. 8, p. 3562-3569
Publication date2003
Abstract

To study the kinetics of polylactide (PLA) nanoparticle (NP) localization within the intraocular tissues and to evaluate their potential to release encapsulated material.

Keywords
  • Animals
  • Biomarkers/analysis
  • Drug Delivery Systems
  • Fluorescent Antibody Technique
  • Indirect
  • Fluorescent Dyes/pharmacokinetics
  • Injections
  • Male
  • Microscopy
  • Confocal
  • Microscopy
  • Electron
  • Scanning
  • Microscopy
  • Fluorescence
  • Microspheres
  • Oxazines/administration & dosage/pharmacokinetics
  • Pigment Epithelium of Eye/metabolism/pathology
  • Polyesters/administration & dosage/pharmacokinetics
  • Rats
  • Rats
  • Inbred Lew
  • Retina/metabolism/pathology/ultrastructure
  • Rhodamines/administration & dosage/pharmacokinetics
  • Tissue Distribution
  • Vitreous Body/metabolism
Affiliation entities Not a UNIGE publication
Research groups
Citation (ISO format)
BOURGES, Jean-Louis et al. Ocular drug delivery targeting the retina and retinal pigment epithelium using polylactide nanoparticles. In: Investigative Ophthalmology & Visual Science, 2003, vol. 44, n° 8, p. 3562–3569.
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
Journal ISSN0146-0404
428views
112downloads

Technical informations

Creation25/09/2017 09:44:00
First validation25/09/2017 09:44:00
Update time15/03/2023 02:27:48
Status update15/03/2023 02:27:47
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