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Title

Quenching-induced deactivation of photosensitizer by nanoencapsulation to improve phototherapy of cancer

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Published in Journal of Drug Targeting. 2009, vol. 17, no. 8, p. 619-626
Abstract Photodynamic therapy has emerged as a promising alternative to current cancer treatment. However, conventional photosensitizers have several limitations due to their unsuitable pharmaceutical formulations and lack of selectivity. Our strategy was to exploit the advantages of nanoparticles and the quenching-induced deactivation of the model photosensitizer hypericin to produce "activatable" drug delivery systems. Efficient fluorescence and activity quenching were achieved by increasing the drug-loading rate of nanoparticles. In vitro assays confirmed the reversibility of hypericin deactivation, as the hypericin fluorescence and photodynamic activity were recovered upon cell internalization.
Keywords Cell Line, TumorDrug Delivery SystemsFemaleFluorescenceHumansNanoparticlesOvarian Neoplasms/therapyPerylene/administration & dosage/analogs & derivativesPhotosensitizing Agents/administration & dosagePhototherapy/methods
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PMID: 19589125
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Article (Published version) (908 Kb) - document accessible for UNIGE members only Limited access to UNIGE
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Research group Technologie pharmaceutique
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ZEISSER-LABOUEBE, Magali et al. Quenching-induced deactivation of photosensitizer by nanoencapsulation to improve phototherapy of cancer. In: Journal of Drug Targeting, 2009, vol. 17, n° 8, p. 619-626. https://archive-ouverte.unige.ch/unige:99551

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Deposited on : 2017-11-23

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