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Title

Appropriate endpoints for evaluation of new antibiotic therapies for severe infections: a perspective from COMBACTE's STAT-Net
Authors
Timsit, Jean-François
de Kraker, Marlieke E A
Sommer, Harriet
Weiss, Emmanuel
Bettiol, Esther
Wolkewitz, Martin
Nikolakopoulos, Stavros
Wilson, David
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Published in Intensive Care Medicine. 2017, vol. 43, no. 7, p. 1002-1012
Abstract In this era of rising antimicrobial resistance, slowly refilling antibiotic development pipelines, and an aging population, we need to ensure that randomized clinical trials (RCTs) determine the added benefit of new antibiotic agents effectively and in a valid way, especially for severely ill patients. Unfortunately, universally accepted endpoints for the evaluation of new drugs in severe infections are lacking.
Identifiers
PMID: 28466147
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Article (Published version) (1 MB) - public document Free access
Structures
Faculté de médecine / Section de médecine clinique / Département de médecine interne
Research group Groupe Harbarth Stephan (Staphylocoques dorés résistants à la méthicilline) (866)
Citation
(ISO format) 		TIMSIT, Jean-François et al. Appropriate endpoints for evaluation of new antibiotic therapies for severe infections: a perspective from COMBACTE's STAT-Net. In: Intensive Care Medicine, 2017, vol. 43, n° 7, p. 1002-1012. doi: 10.1007/s00134-017-4802-4 https://archive-ouverte.unige.ch/unige:99523

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Deposited on : 2017-11-22

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