UNIGE document Scientific Article
previous document  unige:99478  next document
add to browser collection

Protein modelling to understand FGB mutations leading to congenital hypofibrinogenaemia

Aslan, D
Devreese, K
Mondelaers, V
Alberio, L
show hidden authors show all authors [1 - 10]
Published in Haemophilia. 2017, vol. 23, no. 4, p. 583-589
Abstract Congenital hypofibrinogenaemia is a quantitative fibrinogen disorder characterized by proportionally decreased levels of functional and antigenic fibrinogen. Mutations accounting for quantitative fibrinogen disorders are relatively frequent in the conserved COOH-terminal globular domains of the γ and Bβ chains. The latter mutations are of particular interest since the Bβ-chain is considered the rate-limiting chain in the hepatic production of the fibrinogen hexamer.
PMID: 28306188
Full text
Article (Published version) (826 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Research groups Bases moléculaires des anomalies génétiques de l'hémostase (504)
Geneva Platelet Group (13)
(ISO format)
CASINI, Alessandro et al. Protein modelling to understand FGB mutations leading to congenital hypofibrinogenaemia. In: Haemophilia, 2017, vol. 23, n° 4, p. 583-589. https://archive-ouverte.unige.ch/unige:99478

73 hits

1 download


Deposited on : 2017-11-22

Export document
Format :
Citation style :