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Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angiogenesis

Ribeiro-Rodrigues, Teresa M
Laundos, Tiago L
Pereira-Carvalho, Rita
Batista-Almeida, Daniela
Pereira, Ricardo
Coelho-Santos, Vanessa
Silva, Ana P
Fernandes, Rosa
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Published in Cardiovascular Research. 2017, vol. 113, no. 11, p. 1338-1350
Abstract Myocardial infarction (MI) is the leading cause of morbidity and mortality worldwide and results from an obstruction in the blood supply to a region of the heart. In an attempt to replenish oxygen and nutrients to the deprived area, affected cells release signals to promote the development of new vessels and confer protection against MI. However, the mechanisms underlying the growth of new vessels in an ischaemic scenario remain poorly understood. Here, we show that cardiomyocytes subjected to ischaemia release exosomes that elicit an angiogenic response of endothelial cells (ECs).
PMID: 28859292
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Research group L'athérosclérose (665)
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RIBEIRO-RODRIGUES, Teresa M et al. Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angiogenesis. In: Cardiovascular Research, 2017, vol. 113, n° 11, p. 1338-1350. doi: 10.1093/cvr/cvx118 https://archive-ouverte.unige.ch/unige:99475

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Deposited on : 2017-11-22

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