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Scientific article
English

Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angiogenesis

Contributors

Ribeiro-Rodrigues, Teresa M; Laundos, Tiago L; Pereira-Carvalho, Rita; Batista-Almeida, Daniela; Pereira, Ricardo; Coelho-Santos, Vanessa; Silva, Ana P; Fernandes, Rosa; Zuzarte, Monica; Enguita, Francisco J; Costa, Marina C; Pinto-do-Ó, Perpetua; Pinto, Marta T; Gouveia, Pedro; Ferreira, Lino; Mason, Justin C; Pereira, Paulo; Kwak, Brenda; Nascimento, Diana S; Girão, Henrique

Published in

Cardiovascular Research, vol. 113, no. 11, p. 1338-1350

Publication date

2017

Abstract

Myocardial infarction (MI) is the leading cause of morbidity and mortality worldwide and results from an obstruction in the blood supply to a region of the heart. In an attempt to replenish oxygen and nutrients to the deprived area, affected cells release signals to promote the development of new vessels and confer protection against MI. However, the mechanisms underlying the growth of new vessels in an ischaemic scenario remain poorly understood. Here, we show that cardiomyocytes subjected to ischaemia release exosomes that elicit an angiogenic response of endothelial cells (ECs).

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

RIBEIRO-RODRIGUES, Teresa M et al. Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angiogenesis. In: Cardiovascular Research, 2017, vol. 113, n° 11, p. 1338–1350. doi: 10.1093/cvr/cvx118

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

0008-6363
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3downloads

Technical informations

Creation

08/09/2017 09:38:00

First validation

08/09/2017 09:38:00

Update

13/10/2025 19:33:14

Status update

02/04/2025 07:06:55

Last indexation

22/07/2026 10:55:56
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