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Title

Chemoattractant Signals and Adhesion Molecules Promoting Human Regulatory T Cell Recruitment to Porcine Endothelium
Authors
Ehirchiou, Driss
Muller, Yannick D
Chicheportiche, Rachel
Heyrani Nobari, Ruhollah
Madelon, Natacha
Schneider, Mårten K J
Seebach, Jorg Dieter
Published in Transplantation. 2016, vol. 100, no. 4, p. 753-62
Abstract Human CD4+CD25+Foxp3+ T regulatory cells (huTreg) suppress CD4+ T cell-mediated antipig xenogeneic responses in vitro and might therefore be used to induce xenograft tolerance. The present study investigated the role of the adhesion molecules, their porcine ligands, and the chemoattractant factors that may promote the recruitment of huTreg to porcine aortic endothelial cells (PAEC) and their capacity to regulate antiporcine natural killer (NK) cell responses.
Keywords Animals — Cell Adhesion — Cell Adhesion Molecules/immunology/metabolism — Cell Communication — Cell Degranulation — Cells — Cultured — Chemokine CCL17/immunology/metabolism — Chemotaxis — Leukocyte — Coculture Techniques — Cytotoxicity — Immunologic — Endothelial Cells/immunology/metabolism — Flow Cytometry — Heterografts — Humans — Immune Tolerance — Immunophenotyping/methods — Killer Cells — Natural/immunology/metabolism — Phenotype — Signal Transduction — Swine — T-Lymphocytes — Regulatory/immunology/metabolism — Transendothelial and Transepithelial Migration
Identifiers
PMID: 26720299
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Article (Published version) (585 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté de médecine / Section de médecine clinique / Département de médecine
Research group Groupe Seebach Jorg Dieter (transplantation et immunologie) (856)
Citation
(ISO format) 		EHIRCHIOU, Driss et al. Chemoattractant Signals and Adhesion Molecules Promoting Human Regulatory T Cell Recruitment to Porcine Endothelium. In: Transplantation, 2016, vol. 100, n° 4, p. 753-62. doi: 10.1097/TP.0000000000001034 https://archive-ouverte.unige.ch/unige:99470

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Deposited on : 2017-11-22

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