Chemoattractant Signals and Adhesion Molecules Promoting Human Regulatory T Cell Recruitment to Porcine Endothelium

Ehirchiou, Driss; Muller, Yannick D; Chicheportiche, Rachel; Heyrani Nobari, Ruhollah; Madelon, Natacha; Schneider, Mårten K J; Seebach, Jorg Dieter

doi:10.1097/TP.0000000000001034

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Title		Chemoattractant Signals and Adhesion Molecules Promoting Human Regulatory T Cell Recruitment to Porcine Endothelium
Authors		Ehirchiou, Driss Muller, Yannick D Chicheportiche, Rachel Heyrani Nobari, Ruhollah Madelon, Natacha Schneider, Mårten K J Seebach, Jorg Dieter
Published in		Transplantation. 2016, vol. 100, no. 4, p. 753-62
Abstract		Human CD4+CD25+Foxp3+ T regulatory cells (huTreg) suppress CD4+ T cell-mediated antipig xenogeneic responses in vitro and might therefore be used to induce xenograft tolerance. The present study investigated the role of the adhesion molecules, their porcine ligands, and the chemoattractant factors that may promote the recruitment of huTreg to porcine aortic endothelial cells (PAEC) and their capacity to regulate antiporcine natural killer (NK) cell responses.
Keywords		Animals — Cell Adhesion — Cell Adhesion Molecules/immunology/metabolism — Cell Communication — Cell Degranulation — Cells — Cultured — Chemokine CCL17/immunology/metabolism — Chemotaxis — Leukocyte — Coculture Techniques — Cytotoxicity — Immunologic — Endothelial Cells/immunology/metabolism — Flow Cytometry — Heterografts — Humans — Immune Tolerance — Immunophenotyping/methods — Killer Cells — Natural/immunology/metabolism — Phenotype — Signal Transduction — Swine — T-Lymphocytes — Regulatory/immunology/metabolism — Transendothelial and Transepithelial Migration
Identifiers		DOI: 10.1097/TP.0000000000001034 PMID: 26720299
Full text		Article (Published version) (585 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine
Research group		Groupe Seebach Jorg Dieter (transplantation et immunologie) (856)
Citation (ISO format)		EHIRCHIOU, Driss et al. Chemoattractant Signals and Adhesion Molecules Promoting Human Regulatory T Cell Recruitment to Porcine Endothelium. In: Transplantation, 2016, vol. 100, n° 4, p. 753-62. doi: 10.1097/TP.0000000000001034 https://archive-ouverte.unige.ch/unige:99470