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Title

Chemoattractant Signals and Adhesion Molecules Promoting Human Regulatory T Cell Recruitment to Porcine Endothelium

Authors
Muller, Yannick D
Schneider, Mårten K J
Published in Transplantation. 2016, vol. 100, no. 4, p. 753-62
Abstract Human CD4+CD25+Foxp3+ T regulatory cells (huTreg) suppress CD4+ T cell-mediated antipig xenogeneic responses in vitro and might therefore be used to induce xenograft tolerance. The present study investigated the role of the adhesion molecules, their porcine ligands, and the chemoattractant factors that may promote the recruitment of huTreg to porcine aortic endothelial cells (PAEC) and their capacity to regulate antiporcine natural killer (NK) cell responses.
Keywords AnimalsCell AdhesionCell Adhesion Molecules/immunology/metabolismCell CommunicationCell DegranulationCellsCulturedChemokine CCL17/immunology/metabolismChemotaxisLeukocyteCoculture TechniquesCytotoxicityImmunologicEndothelial Cells/immunology/metabolismFlow CytometryHeterograftsHumansImmune ToleranceImmunophenotyping/methodsKiller CellsNatural/immunology/metabolismPhenotypeSignal TransductionSwineT-LymphocytesRegulatory/immunology/metabolismTransendothelial and Transepithelial Migration
Identifiers
PMID: 26720299
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Research group Groupe Seebach Jorg Dieter (transplantation et immunologie) (856)
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EHIRCHIOU, Driss et al. Chemoattractant Signals and Adhesion Molecules Promoting Human Regulatory T Cell Recruitment to Porcine Endothelium. In: Transplantation, 2016, vol. 100, n° 4, p. 753-62. https://archive-ouverte.unige.ch/unige:99470

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Deposited on : 2017-11-22

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