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Scientific article
English

Chemoattractant Signals and Adhesion Molecules Promoting Human Regulatory T Cell Recruitment to Porcine Endothelium

Published inTransplantation, vol. 100, no. 4, p. 753-762
Publication date2016
Abstract

Human CD4+CD25+Foxp3+ T regulatory cells (huTreg) suppress CD4+ T cell-mediated antipig xenogeneic responses in vitro and might therefore be used to induce xenograft tolerance. The present study investigated the role of the adhesion molecules, their porcine ligands, and the chemoattractant factors that may promote the recruitment of huTreg to porcine aortic endothelial cells (PAEC) and their capacity to regulate antiporcine natural killer (NK) cell responses.

Keywords
  • Animals
  • Cell Adhesion
  • Cell Adhesion Molecules/immunology/metabolism
  • Cell Communication
  • Cell Degranulation
  • Cells
  • Cultured
  • Chemokine CCL17/immunology/metabolism
  • Chemotaxis
  • Leukocyte
  • Coculture Techniques
  • Cytotoxicity
  • Immunologic
  • Endothelial Cells/immunology/metabolism
  • Flow Cytometry
  • Heterografts
  • Humans
  • Immune Tolerance
  • Immunophenotyping/methods
  • Killer Cells
  • Natural/immunology/metabolism
  • Phenotype
  • Signal Transduction
  • Swine
  • T-Lymphocytes
  • Regulatory/immunology/metabolism
  • Transendothelial and Transepithelial Migration
Citation (ISO format)
EHIRCHIOU, Driss et al. Chemoattractant Signals and Adhesion Molecules Promoting Human Regulatory T Cell Recruitment to Porcine Endothelium. In: Transplantation, 2016, vol. 100, n° 4, p. 753–762. doi: 10.1097/TP.0000000000001034
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Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0041-1337
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