Low pre-treatment B-cell counts are not a risk factor of infection in patients treated with rituximab for autoimmune diseases: An observational study

Lazarou, Ilias; Finckh, Axel; Fischer, Lara; Ribi, Camillo; Gascon, Danielle; Seebach, Jorg Dieter; Guerne, Pierre-André

doi:10.1016/j.jbspin.2015.05.012

Scientific article

English

Low pre-treatment B-cell counts are not a risk factor of infection in patients treated with rituximab for autoimmune diseases: An observational study

ContributorsLazarou, Ilias; Finckh, Axel

; Fischer, Lara; Ribi, Camillo; Gascon, Danielle; Seebach, Jorg Dieter; Guerne, Pierre-André

Published inJoint, Bone, Spine, vol. 83, no. 2, p. 191-197

Publication date2016

Abstract

Rituximab (RTX) is increasingly used in patients with refractory rheumatoid arthritis (RA) and other severe autoimmune diseases (AID). In practice, many clinicians are reluctant to prescribe RTX in patients with low B-cell counts because of the presumed risk of infection. The aim of this study was therefore to investigate whether B-cell counts before treatment or retreatment with RTX predict the occurrence of infections.

Keywords

Adult
Aged
80 and over
Autoimmune Diseases/drug therapy/immunology
B-Lymphocytes/immunology
Female
Humans
Immunologic Factors/adverse effects/immunology/therapeutic use
Infection/chemically induced/etiology/immunology
Lymphocyte Count
Male
Middle Aged
Risk Factors
Rituximab/adverse effects/immunology/therapeutic use
Young Adult

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

Citation (ISO format)

LAZAROU, Ilias et al. Low pre-treatment B-cell counts are not a risk factor of infection in patients treated with rituximab for autoimmune diseases: An observational study. In: Joint, Bone, Spine, 2016, vol. 83, n° 2, p. 191–197. doi: 10.1016/j.jbspin.2015.05.012

Article (Published version)

Identifiers

PID : unige:99469
DOI : 10.1016/j.jbspin.2015.05.012
PMID : 26677998

Journal ISSN1297-319X

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Low pre-treatment B-cell counts are not a risk factor of infection in patients treated with rituximab for autoimmune diseases: An observational study

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