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Title

A specific anti-citrullinated protein antibody profile identifies a group of rheumatoid arthritis patients with a toll-like receptor 4-mediated disease

Authors
Hatterer, Eric
Shang, Limin
Simonet, Pierre
Herren, Suzanne
Daubeuf, Bruno
Teixeira, Stéphanie
Reilly, James
Elson, Greg
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Published in Arthritis Research and Therapy. 2016, vol. 18, no. 1, p. 224
Abstract Increased expression of toll-like receptor 4 (TLR4) and its endogenous ligands, is characteristic of rheumatoid arthritis (RA) synovitis. In this study, we evaluated how these TLR4 ligands may drive pathogenic processes and whether the fine profiling of anti-citrullinated protein antibodies (ACPA) based on their target specificity might provide a simple means to predict therapeutic benefit when neutralizing TLR4 in this disease.
Identifiers
PMID: 27716430
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Article (Published version) (1.1 MB) - public document Free access
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Research group Mécanisme de l'inflammation articulaire (44)
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HATTERER, Eric et al. A specific anti-citrullinated protein antibody profile identifies a group of rheumatoid arthritis patients with a toll-like receptor 4-mediated disease. In: Arthritis Research and Therapy, 2016, vol. 18, n° 1, p. 224. https://archive-ouverte.unige.ch/unige:99454

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Deposited on : 2017-11-22

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