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Title

Endothelin-1 mediates natriuresis but not polyuria during vitamin D-induced acute hypercalcaemia
Authors
Tokonami, Natsuko
Cheval, Lydie
Monnay, Isabelle
Meurice, Guillaume
Loffing, Johannes
Feraille, Eric
Houillier, Pascal
Published in The Journal of Physiology. 2017, vol. 595, no. 8, p. 2535-2550
Abstract Hypercalcaemia can occur under various pathological conditions, such as primary hyperparathyroidism, malignancy or granulomatosis, and it induces natriuresis and polyuria in various species via an unknown mechanism. A previous study demonstrated that hypercalcaemia induced by vitamin D in rats increased endothelin (ET)-1 expression in the distal nephron, which suggests the involvement of the ET system in hypercalcaemia-induced effects. In the present study, we demonstrate that, during vitamin D-induced hypercalcaemia, the activation of ET system by increased ET-1 is responsible for natriuresis but not for polyuria. Vitamin D-treated hypercalcaemic mice showed a blunted response to amiloride, suggesting that epithelial sodium channel function is inhibited. We have identified an original pathway that specifically mediates the effects of vitamin D-induced hypercalcaemia on sodium handling in the distal nephron without affecting water handling.
Keywords Acute Disease — Animals — Cell Line — Transformed — Endothelin-1/physiology — Hypercalcemia/chemically induced/metabolism/urine — Kidney Tubules/drug effects/metabolism — Male — Mice — Mice — Inbred C57BL — Natriuresis/drug effects/physiology — Polyuria/metabolism/urine — Vitamin D/toxicity
Identifiers
PMID: 28120456
Full text
Article (Published version) (1.9 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme
Research group Groupe Eric Féraille (néphrologie) (29)
Project FNS: 310030_143929/1
Citation
(ISO format) 		TOKONAMI, Natsuko et al. Endothelin-1 mediates natriuresis but not polyuria during vitamin D-induced acute hypercalcaemia. In: The Journal of Physiology, 2017, vol. 595, n° 8, p. 2535-2550. https://archive-ouverte.unige.ch/unige:99453

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Deposited on : 2017-11-22

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