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Endothelin-1 mediates natriuresis but not polyuria during vitamin D-induced acute hypercalcaemia

Tokonami, Natsuko
Cheval, Lydie
Meurice, Guillaume
Loffing, Johannes
Houillier, Pascal
Published in Journal of physiology. 2017, vol. 595, no. 8, p. 2535-2550
Abstract Hypercalcaemia can occur under various pathological conditions, such as primary hyperparathyroidism, malignancy or granulomatosis, and it induces natriuresis and polyuria in various species via an unknown mechanism. A previous study demonstrated that hypercalcaemia induced by vitamin D in rats increased endothelin (ET)-1 expression in the distal nephron, which suggests the involvement of the ET system in hypercalcaemia-induced effects. In the present study, we demonstrate that, during vitamin D-induced hypercalcaemia, the activation of ET system by increased ET-1 is responsible for natriuresis but not for polyuria. Vitamin D-treated hypercalcaemic mice showed a blunted response to amiloride, suggesting that epithelial sodium channel function is inhibited. We have identified an original pathway that specifically mediates the effects of vitamin D-induced hypercalcaemia on sodium handling in the distal nephron without affecting water handling.
Keywords Acute DiseaseAnimalsCell LineTransformedEndothelin-1/physiologyHypercalcemia/chemically induced/metabolism/urineKidney Tubules/drug effects/metabolismMaleMiceMiceInbred C57BLNatriuresis/drug effects/physiologyPolyuria/metabolism/urineVitamin D/toxicity
PMID: 28120456
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Research group Laboratoire de physiologie et pathophysiologie des cellules rénales (29)
Swiss National Science Foundation: 310030_143929
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TOKONAMI, Natsuko et al. Endothelin-1 mediates natriuresis but not polyuria during vitamin D-induced acute hypercalcaemia. In: The Journal of Physiology, 2017, vol. 595, n° 8, p. 2535-2550. doi: 10.1113/JP273610 https://archive-ouverte.unige.ch/unige:99453

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Deposited on : 2017-11-22

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