Scientific article

Endothelin-1 mediates natriuresis but not polyuria during vitamin D-induced acute hypercalcaemia

Published inThe Journal of Physiology, vol. 595, no. 8, p. 2535-2550
Publication date2017

Hypercalcaemia can occur under various pathological conditions, such as primary hyperparathyroidism, malignancy or granulomatosis, and it induces natriuresis and polyuria in various species via an unknown mechanism. A previous study demonstrated that hypercalcaemia induced by vitamin D in rats increased endothelin (ET)-1 expression in the distal nephron, which suggests the involvement of the ET system in hypercalcaemia-induced effects. In the present study, we demonstrate that, during vitamin D-induced hypercalcaemia, the activation of ET system by increased ET-1 is responsible for natriuresis but not for polyuria. Vitamin D-treated hypercalcaemic mice showed a blunted response to amiloride, suggesting that epithelial sodium channel function is inhibited. We have identified an original pathway that specifically mediates the effects of vitamin D-induced hypercalcaemia on sodium handling in the distal nephron without affecting water handling.

  • Acute Disease
  • Animals
  • Cell Line
  • Transformed
  • Endothelin-1/physiology
  • Hypercalcemia/chemically induced/metabolism/urine
  • Kidney Tubules/drug effects/metabolism
  • Male
  • Mice
  • Mice
  • Inbred C57BL
  • Natriuresis/drug effects/physiology
  • Polyuria/metabolism/urine
  • Vitamin D/toxicity
Citation (ISO format)
TOKONAMI, Natsuko et al. Endothelin-1 mediates natriuresis but not polyuria during vitamin D-induced acute hypercalcaemia. In: The Journal of Physiology, 2017, vol. 595, n° 8, p. 2535–2550. doi: 10.1113/JP273610
Main files (1)
Article (Published version)
ISSN of the journal0022-3751

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