Desmoteplase 3 to 9 Hours After Major Artery Occlusion Stroke: The DIAS-4 Trial (Efficacy and Safety Study of Desmoteplase to Treat Acute Ischemic Stroke)

von Kummer, Rüdiger; Mori, Etsuro; Truelsen, Thomas; Jensen, Jens-Kristian S; Grønning, Bjørn A; Fiebach, Jochen B; Lövblad, Karl-Olof; Pedraza, Salvador; Romero, Javier M; Chabriat, Hugues; Chang, Ku-Chou; Dávalos, Antoni; Ford, Gary A; Grotta, James; Kaste, Markku; Schwamm, Lee H; Shuaib, Ashfaq; Albers, Gregory W

doi:10.1161/STROKEAHA.116.013715

Scientific article

English

Desmoteplase 3 to 9 Hours After Major Artery Occlusion Stroke: The DIAS-4 Trial (Efficacy and Safety Study of Desmoteplase to Treat Acute Ischemic Stroke)

Contributorsvon Kummer, Rüdiger; Mori, Etsuro; Truelsen, Thomas; Jensen, Jens-Kristian S; Grønning, Bjørn A; Fiebach, Jochen B; Lövblad, Karl-Olof; Pedraza, Salvador; Romero, Javier M; Chabriat, Hugues; Chang, Ku-Chou; Dávalos, Antoni; Ford, Gary A; Grotta, James; Kaste, Markku; Schwamm, Lee H; Shuaib, Ashfaq; Albers, Gregory W

Published inStroke, vol. 47, no. 12, p. 2880-2887

Publication date2016

Abstract

The DIAS-3 trial (Efficacy and Safety Study of Desmoteplase to Treat Acute Ischemic Stroke [phase 3]) did not demonstrate a significant clinical benefit of desmoteplase administered 3 to 9 hours after stroke in patients with major artery occlusion. We present the results of the prematurely terminated DIAS-4 trial together with a post hoc pooled analysis of the concomitant DIAS-3, DIAS-4, and DIAS-J (Japan) trials to better understand the potential risks and benefits of intravenous desmoteplase for the treatment of ischemic stroke in an extended time window.

Keywords

Aged
Aged
80 and over
Arterial Occlusive Diseases/complications
Brain Ischemia/drug therapy/etiology
Cerebral Arterial Diseases/complications
Early Termination of Clinical Trials
Female
Fibrinolytic Agents/administration & dosage/adverse effects/pharmacology
Follow-Up Studies
Humans
Male
Middle Aged
Outcome Assessment (Health Care)
Plasminogen Activators/administration & dosage/adverse effects/pharmacology
Stroke/drug therapy/etiology

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale

Research groups

Ischémie cérébrale et connectivité (801)

Citation (ISO format)

VON KUMMER, Rüdiger et al. Desmoteplase 3 to 9 Hours After Major Artery Occlusion Stroke: The DIAS-4 Trial (Efficacy and Safety Study of Desmoteplase to Treat Acute Ischemic Stroke). In: Stroke, 2016, vol. 47, n° 12, p. 2880–2887. doi: 10.1161/STROKEAHA.116.013715

Article (Published version)

Identifiers

PID : unige:99446
DOI : 10.1161/STROKEAHA.116.013715
PMID : 27803391

Journal ISSN0039-2499

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Desmoteplase 3 to 9 Hours After Major Artery Occlusion Stroke: The DIAS-4 Trial (Efficacy and Safety Study of Desmoteplase to Treat Acute Ischemic Stroke)

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