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Title

Desmoteplase 3 to 9 Hours After Major Artery Occlusion Stroke: The DIAS-4 Trial (Efficacy and Safety Study of Desmoteplase to Treat Acute Ischemic Stroke)

Authors
von Kummer, Rüdiger
Mori, Etsuro
Truelsen, Thomas
Jensen, Jens-Kristian S
Grønning, Bjørn A
Fiebach, Jochen B
Pedraza, Salvador
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Published in Stroke. 2016, vol. 47, no. 12, p. 2880-2887
Abstract The DIAS-3 trial (Efficacy and Safety Study of Desmoteplase to Treat Acute Ischemic Stroke [phase 3]) did not demonstrate a significant clinical benefit of desmoteplase administered 3 to 9 hours after stroke in patients with major artery occlusion. We present the results of the prematurely terminated DIAS-4 trial together with a post hoc pooled analysis of the concomitant DIAS-3, DIAS-4, and DIAS-J (Japan) trials to better understand the potential risks and benefits of intravenous desmoteplase for the treatment of ischemic stroke in an extended time window.
Keywords AgedAged80 and overArterial Occlusive Diseases/complicationsBrain Ischemia/drug therapy/etiologyCerebral Arterial Diseases/complicationsEarly Termination of Clinical TrialsFemaleFibrinolytic Agents/administration & dosage/adverse effects/pharmacologyFollow-Up StudiesHumansMaleMiddle AgedOutcome Assessment (Health Care)Plasminogen Activators/administration & dosage/adverse effects/pharmacologyStroke/drug therapy/etiology
Identifiers
PMID: 27803391
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Article (Published version) (1 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Ischémie cérébrale et connectivité (801)
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(ISO format)
VON KUMMER, Rüdiger et al. Desmoteplase 3 to 9 Hours After Major Artery Occlusion Stroke: The DIAS-4 Trial (Efficacy and Safety Study of Desmoteplase to Treat Acute Ischemic Stroke). In: Stroke, 2016, vol. 47, n° 12, p. 2880-2887. https://archive-ouverte.unige.ch/unige:99446

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Deposited on : 2017-11-22

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