Scientific article

Percutaneous penetration of drugs: a quantitative structure-permeability relationship study

Published inJournal of pharmaceutical sciences, vol. 80, no. 8, p. 744-749
Publication date1991

Human skin permeation data taken from the literature were analyzed for quantitative relationships with physicochemical properties and structural descriptors. No correlations exist with molecular weights and solvent-accessible surface areas. In most cases, skin permeation was inversely correlated with the parameter delta log Poct-hep (i.e., log Poctanol minus log Pheptane), which is mainly a measure of the H-bond donor acidity of the solutes. Lipophilicity itself, as expressed by log Poctanol, also contributes positively to skin permeation in some cases. The results of this quantitative structure-permeability relationship study are interpreted in terms of a unified mechanistic model whereby drugs can permeate via an intercellular route (correlation with both delta log Poct-hep and log Poct) and/or a transcellular route (correlation with log Poct only).

  • Administration, Topical
  • Alcohols/chemistry/pharmacokinetics
  • Anti-Inflammatory Agents/chemistry
  • Chemistry, Physical
  • Humans
  • Hydrocortisone
  • Hydrogen Bonding
  • Molecular Weight
  • Octanols
  • Phenols/chemistry
  • Physicochemical Phenomena
  • Skin Absorption
  • Solubility
  • Solvents
  • Steroids/chemistry/pharmacokinetics
  • Structure-Activity Relationship
  • Surface Properties
Affiliation Not a UNIGE publication
Citation (ISO format)
EL TAYAR, Nabil et al. Percutaneous penetration of drugs: a quantitative structure-permeability relationship study. In: Journal of pharmaceutical sciences, 1991, vol. 80, n° 8, p. 744–749. doi: 10.1002/jps.2600800807
ISSN of the journal0022-3549

Technical informations

Creation08/06/2010 10:46:44 AM
First validation08/06/2010 10:46:44 AM
Update time03/14/2023 3:56:21 PM
Status update03/14/2023 3:56:21 PM
Last indexation10/18/2023 10:54:59 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack