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Scientific article
Open access
English

CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD

Published inPLOS ONE, vol. 4, no. 10, e7418
Publication date2009
Abstract

Age-related macular degeneration (AMD) is a prevalent cause of blindness in Western societies. Variants in the genes encoding complement factor H (CFH), complement component 3 (C3) and age-related maculopathy susceptibility 2 (ARMS2) have repeatedly been shown to confer significant risks for AMD; however, their role in disease progression and thus their potential relevance for interventional therapeutic approaches remains unknown.

Keywords
  • Aged
  • Aged, 80 and over
  • Cohort Studies
  • Complement C3/metabolism
  • Complement Factor H/metabolism
  • Disease Progression
  • Female
  • Genetic Predisposition to Disease
  • Geographic Atrophy/genetics/pathology
  • Humans
  • Macular Degeneration/genetics/pathology
  • Male
  • Microscopy, Fluorescence/methods
  • Middle Aged
  • Proteins/metabolism
  • Risk
Affiliation Not a UNIGE publication
Citation (ISO format)
SCHOLL, Hendrik P N et al. CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD. In: PLOS ONE, 2009, vol. 4, n° 10, p. e7418. doi: 10.1371/journal.pone.0007418
Main files (1)
Article (Published version)
Identifiers
ISSN of the journal1932-6203
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161downloads

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