CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD

Scholl, Hendrik P N; Fleckenstein, Monika; Fritsche, Lars G; Schmitz-Valckenberg, Steffen; Göbel, Arno; Adrion, Christine; Herold, Christine; Keilhauer, Claudia N; Mackensen, Friederike; Mössner, Andreas; Pauleikhoff, Daniel; Weinberger, Andreas; Mansmann, Ulrich; Holz, Frank G; Becker, Tim; Weber, Bernhard H F

doi:10.1371/journal.pone.0007418

Scientific article

English

CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD

ContributorsScholl, Hendrik P N; Fleckenstein, Monika; Fritsche, Lars G; Schmitz-Valckenberg, Steffen; Göbel, Arno; Adrion, Christine; Herold, Christine; Keilhauer, Claudia N; Mackensen, Friederike; Mössner, Andreas; Pauleikhoff, Daniel; Weinberger, Andreas; Mansmann, Ulrich; Holz, Frank G; Becker, Tim; Weber, Bernhard H F

Published inPLOS ONE, vol. 4, no. 10, e7418

Publication date2009

Abstract

Age-related macular degeneration (AMD) is a prevalent cause of blindness in Western societies. Variants in the genes encoding complement factor H (CFH), complement component 3 (C3) and age-related maculopathy susceptibility 2 (ARMS2) have repeatedly been shown to confer significant risks for AMD; however, their role in disease progression and thus their potential relevance for interventional therapeutic approaches remains unknown.

Keywords

Aged
Aged, 80 and over
Cohort Studies
Complement C3/metabolism
Complement Factor H/metabolism
Disease Progression
Female
Genetic Predisposition to Disease
Geographic Atrophy/genetics/pathology
Humans
Macular Degeneration/genetics/pathology
Male
Microscopy, Fluorescence/methods
Middle Aged
Proteins/metabolism
Risk

Affiliation entities

Not a UNIGE publication

Citation (ISO format)

SCHOLL, Hendrik P N et al. CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD. In: PLOS ONE, 2009, vol. 4, n° 10, p. e7418. doi: 10.1371/journal.pone.0007418

Article (Published version)

CC BY

Identifiers

PID : unige:99142
DOI : 10.1371/journal.pone.0007418
PMID : 19823576

Journal ISSN1932-6203

448views

241downloads

Creation19/07/2017 15:26:00

First validation19/07/2017 15:26:00

Update15/03/2023 02:22:24

Status update15/03/2023 02:22:23

Last indexation31/10/2024 08:37:05

Archive ouverte UNIGE

CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD

Technical informations