Article (Published version) (178 Kb) - Free access
CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD.
|Published in||PLOS ONE. 2009, vol. 4, no. 10, p. e7418|
|Abstract||Age-related macular degeneration (AMD) is a prevalent cause of blindness in Western societies. Variants in the genes encoding complement factor H (CFH), complement component 3 (C3) and age-related maculopathy susceptibility 2 (ARMS2) have repeatedly been shown to confer significant risks for AMD; however, their role in disease progression and thus their potential relevance for interventional therapeutic approaches remains unknown.|
|Keywords||Aged — Aged, 80 and over — Cohort Studies — Complement C3/metabolism — Complement Factor H/metabolism — Disease Progression — Female — Genetic Predisposition to Disease — Geographic Atrophy/genetics/pathology — Humans — Macular Degeneration/genetics/pathology — Male — Microscopy, Fluorescence/methods — Middle Aged — Proteins/metabolism — Risk|
|SCHOLL, Hendrik P N et al. CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD. In: PLOS ONE, 2009, vol. 4, n° 10, p. e7418. doi: 10.1371/journal.pone.0007418 https://archive-ouverte.unige.ch/unige:99142|