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Title

CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD.

Authors
Scholl, Hendrik P N
Fleckenstein, Monika
Fritsche, Lars G
Schmitz-Valckenberg, Steffen
Göbel, Arno
Adrion, Christine
Herold, Christine
Keilhauer, Claudia N
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Published in PLOS ONE. 2009, vol. 4, no. 10, p. e7418
Abstract Age-related macular degeneration (AMD) is a prevalent cause of blindness in Western societies. Variants in the genes encoding complement factor H (CFH), complement component 3 (C3) and age-related maculopathy susceptibility 2 (ARMS2) have repeatedly been shown to confer significant risks for AMD; however, their role in disease progression and thus their potential relevance for interventional therapeutic approaches remains unknown.
Keywords AgedAged, 80 and overCohort StudiesComplement C3/metabolismComplement Factor H/metabolismDisease ProgressionFemaleGenetic Predisposition to DiseaseGeographic Atrophy/genetics/pathologyHumansMacular Degeneration/genetics/pathologyMaleMicroscopy, Fluorescence/methodsMiddle AgedProteins/metabolismRisk
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PMID: 19823576
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SCHOLL, Hendrik P N et al. CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD. In: PLOS ONE, 2009, vol. 4, n° 10, p. e7418. https://archive-ouverte.unige.ch/unige:99142

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Deposited on : 2017-11-17

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