• Home
  1. Home
  2. Clinical validity of medial temporal atrophy as a biomarker for Alzheimer's disease in the context of a structured 5-phase development framework
Scientific article
English

Clinical validity of medial temporal atrophy as a biomarker for Alzheimer's disease in the context of a structured 5-phase development framework

Contributors

Ten Kate, Mara; Barkhof, Frederik; Boccardi, Marina; Visser, Pieter Jelle; Jack, Clifford R (Jr); Lövblad, Karl-Olof; Frisoni, Giovanni; Scheltens, Philip

Published in

Neurobiology of Aging, vol. 52, p. 167-182.e1

Publication date

2017

Abstract

Research criteria for Alzheimer's disease recommend the use of biomarkers for diagnosis, but whether biomarkers improve the diagnosis in clinical routine has not been systematically assessed. The aim is to evaluate the evidence for use of medial temporal lobe atrophy (MTA) as a biomarker for Alzheimer's disease at the mild cognitive impairment stage in routine clinical practice, with an adapted version of the 5-phase oncology framework for biomarker development. A literature review on visual assessment of MTA and hippocampal volumetry was conducted with other biomarkers addressed in parallel reviews. Ample evidence is available for phase 1 (rationale for use) and phase 2 (discriminative ability between diseased and control subjects). Phase 3 (early detection ability) is partly achieved: most evidence is derived from research cohorts or clinical populations with short follow-up, but validation in clinical mild cognitive impairment cohorts is required. In phase 4, only the practical feasibility has been addressed for visual rating of MTA. The rest of phase 4 and phase 5 have not yet been addressed.

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

TEN KATE, Mara et al. Clinical validity of medial temporal atrophy as a biomarker for Alzheimer’s disease in the context of a structured 5-phase development framework. In: Neurobiology of Aging, 2017, vol. 52, p. 167–182.e1. doi: 10.1016/j.neurobiolaging.2016.05.024

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

0197-4580
425views
0downloads

Technical informations

Creation

30/08/2017 14:26:00

First validation

30/08/2017 14:26:00

Update

15/03/2023 02:22:04

Status update

15/03/2023 02:22:03

Last indexation

31/10/2024 08:36:19
All rights reserved by Archive ouverte UNIGE and the University of Geneva
OpenAIRE Indexed & Validated