Rituximab in B-Lineage Adult Acute Lymphoblastic Leukemia

Maury, Sébastien; Chevret, Sylvie; Thomas, Xavier; Heim, Dominik; Leguay, Thibaut; Huguet, Françoise; Chevallier, Patrice; Hunault, Mathilde; Boissel, Nicolas; Escoffre-Barbe, Martine; Hess, Urs; Vey, Norbert; Pignon, Jean-Michel; Braun, Thorsten; Marolleau, Jean-Pierre; Cahn, Jean-Yves; Chalandon, Yves; Lhéritier, Véronique; Beldjord, Kheira; Béné, Marie C; Ifrah, Norbert; Dombret, Hervé

doi:10.1056/NEJMoa1605085

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Title		Rituximab in B-Lineage Adult Acute Lymphoblastic Leukemia
Authors		Maury, Sébastien Chevret, Sylvie Thomas, Xavier Heim, Dominik Leguay, Thibaut Huguet, Françoise Chevallier, Patrice Hunault, Mathilde Boissel, Nicolas Escoffre-Barbe, Martine Hess, Urs Vey, Norbert Pignon, Jean-Michel Braun, Thorsten Marolleau, Jean-Pierre Cahn, Jean-Yves Chalandon, Yves Lhéritier, Véronique Beldjord, Kheira Béné, Marie C Ifrah, Norbert Dombret, Hervé show all authors [1 - 22]
Published in		New England Journal of Medicine. 2016, vol. 375, no. 11, p. 1044-1053
Abstract		Treatment with rituximab has improved the outcome for patients with non-Hodgkin's lymphoma. Patients with B-lineage acute lymphoblastic leukemia (ALL) may also have the CD20 antigen, which is targeted by rituximab. Although single-group studies suggest that adding rituximab to chemotherapy could improve the outcome in such patients, this hypothesis has not been tested in a randomized trial.
Keywords		Adolescent — Adult — Antigens, CD20/analysis — Antineoplastic Combined Chemotherapy Protocols/adverse effects/therapeutic use — Disease-Free Survival — Female — Follow-Up Studies — Humans — Male — Middle Aged — Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy/immunology — Prognosis — Remission Induction — Rituximab/administration & dosage/adverse effects — Young Adult
Identifiers		DOI: 10.1056/NEJMoa1605085 PMID: 27626518
Full text		Article (Published version) (294 Kb) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine
Research group		Leucémie et transplantation allogénique de cellules souches hématopoïétiques (982)
Citation (ISO format)		MAURY, Sébastien et al. Rituximab in B-Lineage Adult Acute Lymphoblastic Leukemia. In: New England Journal of Medicine, 2016, vol. 375, n° 11, p. 1044-1053. doi: 10.1056/NEJMoa1605085 https://archive-ouverte.unige.ch/unige:99092