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Impact of cytogenetic abnormalities in adults with Ph-negative B-cell precursor acute lymphoblastic leukemia

Lafage-Pochitaloff, Marina
Baranger, Laurence
Hunault, Mathilde
Cuccuini, Wendy
Lefebvre, Christine
Bidet, Audrey
Tigaud, Isabelle
Eclache, Virginie
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Published in Blood. 2017, vol. 130, no. 16, p. 1832-1844
Abstract Multiple cytogenetic subgroups have been described in adult Philadelphia chromosome (Ph)-negative B-cell precursor (BCP) acute lymphoblastic leukemia (ALL), often comprising small numbers of patients. In this study, we aimed to reassess the prognostic value of cytogenetic abnormalities in a large series of 617 adult patients with Ph-negative BCP-ALL (median age, 38 years), treated in the intensified Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL)-2003/2005 trials. Combined data from karyotype, DNA index, fluorescence in situ hybridization, and polymerase chain reaction screening for relevant abnormalities were centrally reviewed and were informative in 542 cases (88%), allowing classification in 10 exclusive primary cytogenetic subgroups and in secondary subgroups, including complex and monosomal karyotypes. Prognostic analyses focused on cumulative incidence of failure (including primary refractoriness and relapse), event-free survival, and overall survival. Only 2 subgroups, namely t(4;11)/KMT2A-AFF1 and 14q32/IGH translocations, displayed a significantly worse outcome in this context, still observed after adjustment for age and after censoring patients who received allogeneic stem cell transplantation (SCT) in first remission at SCT time. A worse outcome was also observed in patients with low hypodiploidy/near triploidy, but this was likely related to their higher age and worse tolerance to therapy. The other cytogenetic abnormalities, including complex and monosomal karyotypes, had no prognostic value in these intensive protocols designed for adult patients up to the age of 60 years.
Keywords AdolescentAdultChromosome Aberrations/statistics & numerical dataClinical Trials as Topic/statistics & numerical dataCytogenetic AnalysisFemaleHumansKaryotypingMaleMiddle AgedMulticenter Studies as Topic/statistics & numerical dataPhiladelphia ChromosomePrecursor B-Cell Lymphoblastic Leukemia-Lymphoma/diagnosis/epidemiology/genetics/therapyPredictive Value of TestsPrognosisRetrospective StudiesYoung Adult
PMID: 28790105
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Research group Leucémie et transplantation allogénique de cellules souches hématopoïétiques (982)
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LAFAGE-POCHITALOFF, Marina et al. Impact of cytogenetic abnormalities in adults with Ph-negative B-cell precursor acute lymphoblastic leukemia. In: Blood, 2017, vol. 130, n° 16, p. 1832-1844. doi: 10.1182/blood-2017-05-783852 https://archive-ouverte.unige.ch/unige:99086

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Deposited on : 2017-11-16

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