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Titles listIonization behavior and ionization-dependent conformation of raclopride, a dopamine-D2 receptor antagonist
Titles listIonization behavior and ionization-dependent conformation of raclopride, a dopamine-D2 receptor antagonist
Scientific Article
unige:9908 
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Ionization behavior and ionization-dependent conformation of raclopride, a dopamine-D2 receptor antagonist |
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| Authors | ||
| Published in | Helvetica Chimica Acta. 1991, vol. 74, no. 5, p. 956 | |
| Abstract | Raclopride, an antipsychotic 6-methoxysalicylamide ( = 2-hydroxy-6-methoxybenzamide) derivative, was shown by titrimetry and UV-photometry to exist in zwitterionic form at physiological pH. Calculations revealed that the neutral and zwitterionic forms differ considerably in their conformational behavior, the latter form being energetically favored by an intramolecular phenolate-ammonium ionic bond. These findings indicate that raclopride and other halogenated 6-methoxysalicylamides with a highly acidic phenolic group may not resemble other ortho-methoxybenzamides in their stereoelectronic structure and mode of binding to the dopamine D2 receptor | |
| Full text | ||
| Citation (ISO format) | CARRUPT, Pierre-Alain et al. Ionization behavior and ionization-dependent conformation of raclopride, a dopamine-D2 receptor antagonist. In: Helvetica Chimica Acta, 1991, vol. 74, n° 5, p. 956. https://archive-ouverte.unige.ch/unige:9908 |
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