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Safety, immunogenicity, and preliminary clinical efficacy of a vaccine against extraintestinal pathogenic Escherichia coli in women with a history of recurrent urinary tract infection: a randomised, single-blind, placebo-controlled phase 1b trial

Published inThe Lancet Infectious Diseases, vol. 17, no. 5, p. 528-537
Publication date2017
Abstract

Escherichia coli infections are increasing worldwide in community and hospital settings. The E coli O-antigen is a promising vaccine target. We aimed to assess the safety and immunogenicity of a bioconjugate vaccine containing the O-antigens of four E coli serotypes (ExPEC4V).

Keywords
  • Adult
  • Aged
  • Escherichia coli Vaccines/administration & dosage/therapeutic use
  • Extraintestinal Pathogenic Escherichia coli/isolation & purification
  • Female
  • Humans
  • Immunogenicity, Vaccine
  • Middle Aged
  • Single-Blind Method
  • Treatment Outcome
  • Urinary Tract Infections/prevention & control
  • Vaccination/methods
Citation (ISO format)
CSAKI HUTTNER, Angela et al. Safety, immunogenicity, and preliminary clinical efficacy of a vaccine against extraintestinal pathogenic Escherichia coli in women with a history of recurrent urinary tract infection: a randomised, single-blind, placebo-controlled phase 1b trial. In: The Lancet Infectious Diseases, 2017, vol. 17, n° 5, p. 528–537. doi: 10.1016/S1473-3099(17)30108-1
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ISSN of the journal1473-3099
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Technical informations

Creation10/20/2017 7:23:00 PM
First validation10/20/2017 7:23:00 PM
Update time03/15/2023 2:20:58 AM
Status update03/15/2023 2:20:56 AM
Last indexation05/02/2024 7:41:24 PM
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