Multipotent mesenchymal stromal cells enhance insulin secretion from human islets via N-cadherin interaction and prolong function of transplanted encapsulated islets in mice

Montanari, Elisa; Meier, Raphaël; Mahou, Redouan; Seebach, Jorg Dieter; Wandrey, Christine; Gerber-Lemaire, Sandrine; Buehler, Leo Hans; Gonelle-Gispert, Carmen

doi:10.1186/s13287-017-0646-7

Scientific article

Open access

English

Multipotent mesenchymal stromal cells enhance insulin secretion from human islets via N-cadherin interaction and prolong function of transplanted encapsulated islets in mice

ContributorsMontanari, Elisa; Meier, Raphaël; Mahou, Redouan; Seebach, Jorg Dieter; Wandrey, Christine; Gerber-Lemaire, Sandrine; Buehler, Leo Hans; Gonelle-Gispert, Carmen

Published inStem Cell Research and Therapy, vol. 8, no. 1, 199

Publication date2017

Abstract

Multipotent mesenchymal stromal cells (MSC) enhance viability and function of islets of Langerhans. We aimed to examine the interactions between human MSC and human islets of Langerhans that influence the function of islets.

Keywords

Cell interaction
Encapsulation
Human islets
Mesenchymal stromal cells
N-cadherin

Affiliation

Research group

Citation (ISO format)

MONTANARI, Elisa et al. Multipotent mesenchymal stromal cells enhance insulin secretion from human islets via N-cadherin interaction and prolong function of transplanted encapsulated islets in mice. In: Stem Cell Research and Therapy, 2017, vol. 8, n° 1, p. 199. doi: 10.1186/s13287-017-0646-7