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Title

Electronic and Conformational Effects on the Lipophilicity of Isomers and Analogs of the Neurotoxin 1-Methyl-4-Phenylpyridinium (Mpp+)
Authors
Altomare, Cosimo
Carrupt, Pierre-Alain
el Tayar, Nabil
Testa, Bernard
Nagatsu, T.
Published in Helvetica chimica acta. 1991, vol. 74, no. 2, p. 290-296
Abstract A number of isomers and analogs of the neurotoxin 1-methyl-4-phenylpyridinium (MPP+) were examined for their lipophilic behavior. Their partition coefficients in the 1-octanol/H-2O system were measured by centrifugal partition chromatography (CPC), which, being much faster and markedly more precise than the classical shakeflask method, proved a very promising alternative for assessing lipophilicity. A smaller-than-expected lipophilicity was shown by the ortho-isomer of MPP+ (M2PP+) and is explained in terms of electronic effects and rigidity, as revealed by UV and NMR spectroscopy, and conformational analysis. Implications of lipophilicity in modulating the in vivo dopaminergic neurotoxicity of the examined compounds are also discussed
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(ISO format) 		ALTOMARE, Cosimo et al. Electronic and Conformational Effects on the Lipophilicity of Isomers and Analogs of the Neurotoxin 1-Methyl-4-Phenylpyridinium (Mpp+). In: Helvetica chimica acta, 1991, vol. 74, n° 2, p. 290-296. doi: 10.1002/hlca.19910740205 https://archive-ouverte.unige.ch/unige:9890

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Deposited on : 2010-08-06

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