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Title

EBI2 Expression and Function: Robust in Memory Lymphocytes and Increased by Natalizumab in Multiple Sclerosis

Authors
Mathias, Amandine
Sailer, Andreas W
Schluep, Myriam
Du Pasquier, Renaud
Published in Cell Reports. 2017, vol. 18, no. 1, p. 213-224
Abstract The interaction between oxysterols and the G protein-coupled receptor Epstein-Barr virus-induced gene 2 (EBI2) fine-tunes immune cell migration, a mechanism efficiently targeted by several disease-modifying treatments developed to treat multiple sclerosis (MS), such as natalizumab. We previously showed that memory CD4(+) T lymphocytes migrate specifically in response to 7α,25-dihydroxycholesterol (7α,25-OHC) via EBI2 in the MS murine model experimental autoimmune encephalomyelitis. However, the EBI2 expression profile in human lymphocytes in both healthy and MS donors is unknown. Here, we characterize EBI2 biology in human lymphocytes. We observed that EBI2 is functionally expressed on memory CD4(+) T cells and is enhanced under natalizumab treatment. These data suggest a significant role for EBI2 in human CD4(+) T cell migration, notably in patients with MS. Better knowledge of EBI2 involvement in autoimmunity may therefore lead to an improved understanding of the physiopathology of MS.
Identifiers
PMID: 28052250
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Research group Groupe Seebach Jorg Dieter (transplantation et immunologie) (856)
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CLOTTU, Aurélie Sarah et al. EBI2 Expression and Function: Robust in Memory Lymphocytes and Increased by Natalizumab in Multiple Sclerosis. In: Cell Reports, 2017, vol. 18, n° 1, p. 213-224. https://archive-ouverte.unige.ch/unige:98888

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Deposited on : 2017-11-10

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