EBI2 Expression and Function: Robust in Memory Lymphocytes and Increased by Natalizumab in Multiple Sclerosis

Clottu, Aurélie Sarah; Mathias, Amandine; Sailer, Andreas W; Schluep, Myriam; Seebach, Jorg Dieter; Du Pasquier, Renaud; Pot, Caroline

doi:10.1016/j.celrep.2016.12.006

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Title		EBI2 Expression and Function: Robust in Memory Lymphocytes and Increased by Natalizumab in Multiple Sclerosis
Authors		Clottu, Aurélie Sarah Mathias, Amandine Sailer, Andreas W Schluep, Myriam Seebach, Jorg Dieter Du Pasquier, Renaud Pot, Caroline
Published in		Cell reports. 2017, vol. 18, no. 1, p. 213-224
Abstract		The interaction between oxysterols and the G protein-coupled receptor Epstein-Barr virus-induced gene 2 (EBI2) fine-tunes immune cell migration, a mechanism efficiently targeted by several disease-modifying treatments developed to treat multiple sclerosis (MS), such as natalizumab. We previously showed that memory CD4(+) T lymphocytes migrate specifically in response to 7α,25-dihydroxycholesterol (7α,25-OHC) via EBI2 in the MS murine model experimental autoimmune encephalomyelitis. However, the EBI2 expression profile in human lymphocytes in both healthy and MS donors is unknown. Here, we characterize EBI2 biology in human lymphocytes. We observed that EBI2 is functionally expressed on memory CD4(+) T cells and is enhanced under natalizumab treatment. These data suggest a significant role for EBI2 in human CD4(+) T cell migration, notably in patients with MS. Better knowledge of EBI2 involvement in autoimmunity may therefore lead to an improved understanding of the physiopathology of MS.
Identifiers		DOI: 10.1016/j.celrep.2016.12.006 PMID: 28052250
Full text		Article (Published version) (2.2 MB) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Research group		Laboratoire d'immunologie translationnelle (856)
Citation (ISO format)		CLOTTU, Aurélie Sarah et al. EBI2 Expression and Function: Robust in Memory Lymphocytes and Increased by Natalizumab in Multiple Sclerosis. In: Cell Reports, 2017, vol. 18, n° 1, p. 213-224. doi: 10.1016/j.celrep.2016.12.006 https://archive-ouverte.unige.ch/unige:98888