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Scientific article
English

Human anti-pig NK cell and CD8(+) T-cell responses in the presence of regulatory dendritic cells

Published inXenotransplantation, vol. 23, no. 6, p. 479-489
Publication date2016
Abstract

Dendritic cells (DC) play a major role in natural killer (NK) cell and cytotoxic T lymphocyte (CTL) activation leading to cell-mediated xenogeneic responses. In contrast, the use of in vitro differentiated regulatory DC may represent an attractive approach to protect porcine endothelial cells (pEC) from human cell-mediated immune responses. In this study, we evaluated the potential of human regulatory DC to reduce xenogeneic NK cell and CTL responses to pEC.

Citation (ISO format)
MADELON, Natacha, PUGA YUNG, Gisella, SEEBACH, Jorg Dieter. Human anti-pig NK cell and CD8(+) T-cell responses in the presence of regulatory dendritic cells. In: Xenotransplantation, 2016, vol. 23, n° 6, p. 479–489. doi: 10.1111/xen.12279
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ISSN of the journal0908-665X
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