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Human anti-pig NK cell and CD8(+) T-cell responses in the presence of regulatory dendritic cells

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Published in Xenotransplantation. 2016, vol. 23, no. 6, p. 479-489
Abstract Dendritic cells (DC) play a major role in natural killer (NK) cell and cytotoxic T lymphocyte (CTL) activation leading to cell-mediated xenogeneic responses. In contrast, the use of in vitro differentiated regulatory DC may represent an attractive approach to protect porcine endothelial cells (pEC) from human cell-mediated immune responses. In this study, we evaluated the potential of human regulatory DC to reduce xenogeneic NK cell and CTL responses to pEC.
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PMID: 27862343
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Article (Published version) (1.1 MB) - document accessible for UNIGE members only Limited access to UNIGE
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Research group Laboratoire d'immunologie translationnelle (856)
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MADELON, Natacha, PUGA YUNG, Gisella, SEEBACH, Jorg Dieter. Human anti-pig NK cell and CD8(+) T-cell responses in the presence of regulatory dendritic cells. In: Xenotransplantation, 2016, vol. 23, n° 6, p. 479-489. doi: 10.1111/xen.12279 https://archive-ouverte.unige.ch/unige:98887

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Deposited on : 2017-11-10

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