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The role of female hormonal factors in the development of rheumatoid arthritis

Canny, Geraldine
Published in Rheumatology. 2017, vol. 56, no. 8, p. 1254-1263
Abstract RA is the most common chronic systemic autoimmune disease, with a higher prevalence in women, suggesting female hormonal factors play a role in the development of the disease. However, many controversies still exist. The aim of this review was to appraise data from recent research concerning female hormonal factors and their association with RA disease development. The study of female hormonal factors is challenging because serum levels may differ throughout a woman's lifetime and interact with various environmental, immunological, genetic and endocrine factors influencing the development of autoimmunity. As some female hormonal factors may be potentially modifiable, understanding their impact on RA development is clinically relevant and may result in specific preventive interventions in high-risk populations.
Keywords Arthritis, Rheumatoid/blood/immunologyAutoimmunityEstrogens/blood/immunologyFemaleGonadal Hormones/blood/immunologyHumansProgesterone/blood/immunologyRisk FactorsSex Factors
PMID: 27686101
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Research groups Mécanisme de l'inflammation articulaire (44)
Recherche clinique en rhumatismes inflammatoires (1010)
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ALPIZAR RODRIGUEZ, Deshire et al. The role of female hormonal factors in the development of rheumatoid arthritis. In: Rheumatology, 2017, vol. 56, n° 8, p. 1254-1263. doi: 10.1093/rheumatology/kew318 https://archive-ouverte.unige.ch/unige:98882

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Deposited on : 2017-11-10

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