Scientific article
English

The role of female hormonal factors in the development of rheumatoid arthritis

Published inRheumatology, vol. 56, no. 8, p. 1254-1263
Publication date2017
Abstract

RA is the most common chronic systemic autoimmune disease, with a higher prevalence in women, suggesting female hormonal factors play a role in the development of the disease. However, many controversies still exist. The aim of this review was to appraise data from recent research concerning female hormonal factors and their association with RA disease development. The study of female hormonal factors is challenging because serum levels may differ throughout a woman's lifetime and interact with various environmental, immunological, genetic and endocrine factors influencing the development of autoimmunity. As some female hormonal factors may be potentially modifiable, understanding their impact on RA development is clinically relevant and may result in specific preventive interventions in high-risk populations.

Keywords
  • Arthritis, Rheumatoid/blood/immunology
  • Autoimmunity
  • Estrogens/blood/immunology
  • Female
  • Gonadal Hormones/blood/immunology
  • Humans
  • Progesterone/blood/immunology
  • Risk Factors
  • Sex Factors
Citation (ISO format)
ALPIZAR RODRIGUEZ, Deshire et al. The role of female hormonal factors in the development of rheumatoid arthritis. In: Rheumatology, 2017, vol. 56, n° 8, p. 1254–1263. doi: 10.1093/rheumatology/kew318
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
Journal ISSN1462-0324
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