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Elevated serum levels of free interleukin-18 in adult-onset Still's disease

Rech, Jürgen
Brown, Michael
Spertini, François
Schiffrin, Eduardo J
Schett, Georg
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Published in Rheumatology. 2016, vol. 55, no. 12, p. 2237-2247
Abstract IL-18 is a pro-inflammatory cytokine of the IL-1 family that is naturally inhibited by IL-18 binding protein (IL-18BP). High levels of IL-18 have been described in the serum of adult-onset Still's disease (AOSD) patients, but only total IL-18 levels (including inactive IL-18 bound to IL-18BP) have been measured. With a specific immunoassay, we aimed to measure free IL-18 serum levels in AOSD patients and other rheumatic diseases.
Keywords AdultAgedAlanine Transaminase/metabolismBiomarkers/metabolismC-Reactive Protein/metabolismCase-Control StudiesCytokines/metabolismEnzyme-Linked Immunosorbent AssayFemaleFerritins/metabolismHumansIntercellular Signaling Peptides and Proteins/metabolismInterleukin-18/metabolismLeukocytosis/physiopathologyMaleMiddle AgedProtein BindingStill's Disease, Adult-Onset/blood
PMID: 27616144
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Research groups Etude de l'activation des monocytes/macrophages et des polynucléaires neutrophiles (779)
Mécanisme de l'inflammation articulaire (44)
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GIRARD, Charlotte et al. Elevated serum levels of free interleukin-18 in adult-onset Still's disease. In: Rheumatology, 2016, vol. 55, n° 12, p. 2237-2247. doi: 10.1093/rheumatology/kew300 https://archive-ouverte.unige.ch/unige:98877

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Deposited on : 2017-11-10

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