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Elevated serum levels of free interleukin-18 in adult-onset Still's disease

ContributorsGirard, Charlotte; Rech, Jürgen; Brown, Michael; Allali, Danièle; Roux-Lombard, Pascale; Spertini, François; Schiffrin, Eduardo J; Schett, Georg; Manger, Bernhard; Bas, Sylvette; Del Val, Greg; Gabay, Cem
Published inRheumatology, vol. 55, no. 12, p. 2237-2247
Publication date2016
Abstract

IL-18 is a pro-inflammatory cytokine of the IL-1 family that is naturally inhibited by IL-18 binding protein (IL-18BP). High levels of IL-18 have been described in the serum of adult-onset Still's disease (AOSD) patients, but only total IL-18 levels (including inactive IL-18 bound to IL-18BP) have been measured. With a specific immunoassay, we aimed to measure free IL-18 serum levels in AOSD patients and other rheumatic diseases.

Keywords
  • Adult
  • Aged
  • Alanine Transaminase/metabolism
  • Biomarkers/metabolism
  • C-Reactive Protein/metabolism
  • Case-Control Studies
  • Cytokines/metabolism
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Ferritins/metabolism
  • Humans
  • Intercellular Signaling Peptides and Proteins/metabolism
  • Interleukin-18/metabolism
  • Leukocytosis/physiopathology
  • Male
  • Middle Aged
  • Protein Binding
  • Still's Disease, Adult-Onset/blood
Affiliation entities
Research groups
Citation (ISO format)
GIRARD, Charlotte et al. Elevated serum levels of free interleukin-18 in adult-onset Still’s disease. In: Rheumatology, 2016, vol. 55, n° 12, p. 2237–2247. doi: 10.1093/rheumatology/kew300
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accessLevelRestricted
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Journal ISSN1462-0324
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