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Successful Prevention of Transmission of Integrase Resistance in the Swiss HIV Cohort Study

Scherrer, Alexandra U
Yang, Wan-Lin
Kouyos, Roger D
Böni, Jürg
Klimkait, Thomas
Cavassini, Matthias
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Published in The Journal of Infectious Diseases. 2016, vol. 214, no. 3, p. 399-402
Abstract The prevalence of integrase strand transfer inhibitor (INSTI)-transmitted drug resistance (TDR) may increase with the increasing use of INSTIs. We analyzed the prevalence of INSTI TDR in the Swiss HIV Cohort Study (2008-2014). In 1 of 1316 drug-naive samples (0.1%), a major INSTI TDR mutation was detected. Prevalence was stable, although INSTIs were increasingly used. We showed that this is in contrast to the introduction of previous drug classes, in which more treatment failures with resistant strains occurred and TDR was observed more rapidly. We demonstrated on a population-level that it is possible to avoid TDR to a new drug class for years.
Keywords Anti-HIV Agents/pharmacologyCohort StudiesDisease TransmissionInfectiousDrug ResistanceViralDrug UtilizationHIV/drug effects/genetics/isolation & purificationHIV Infections/drug therapy/epidemiology/transmission/virologyHIV Integrase/geneticsHIV Integrase Inhibitors/therapeutic useHumansPrevalenceSwitzerland/epidemiology
PMID: 27130429
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Article (Published version) (233 Kb) - public document Free access
Research groups Groupe Laurent Kaiser (virologie clinique) (668)
VIH/SIDA (930)
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SCHERRER, Alexandra U et al. Successful Prevention of Transmission of Integrase Resistance in the Swiss HIV Cohort Study. In: The Journal of Infectious Diseases, 2016, vol. 214, n° 3, p. 399-402. doi: 10.1093/infdis/jiw165 https://archive-ouverte.unige.ch/unige:98823

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Deposited on : 2017-11-09

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