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Scientific article
Open access
English

Successful Prevention of Transmission of Integrase Resistance in the Swiss HIV Cohort Study

Published inThe Journal of Infectious Diseases, vol. 214, no. 3, p. 399-402
Publication date2016
Abstract

The prevalence of integrase strand transfer inhibitor (INSTI)-transmitted drug resistance (TDR) may increase with the increasing use of INSTIs. We analyzed the prevalence of INSTI TDR in the Swiss HIV Cohort Study (2008-2014). In 1 of 1316 drug-naive samples (0.1%), a major INSTI TDR mutation was detected. Prevalence was stable, although INSTIs were increasingly used. We showed that this is in contrast to the introduction of previous drug classes, in which more treatment failures with resistant strains occurred and TDR was observed more rapidly. We demonstrated on a population-level that it is possible to avoid TDR to a new drug class for years.

Keywords
  • Anti-HIV Agents/pharmacology
  • Cohort Studies
  • Disease Transmission
  • Infectious
  • Drug Resistance
  • Viral
  • Drug Utilization
  • HIV/drug effects/genetics/isolation & purification
  • HIV Infections/drug therapy/epidemiology/transmission/virology
  • HIV Integrase/genetics
  • HIV Integrase Inhibitors/therapeutic use
  • Humans
  • Prevalence
  • Switzerland/epidemiology
Citation (ISO format)
SCHERRER, Alexandra U et al. Successful Prevention of Transmission of Integrase Resistance in the Swiss HIV Cohort Study. In: The Journal of Infectious Diseases, 2016, vol. 214, n° 3, p. 399–402. doi: 10.1093/infdis/jiw165
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Article (Published version)
Identifiers
ISSN of the journal0022-1899
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162downloads

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