Successful Prevention of Transmission of Integrase Resistance in the Swiss HIV Cohort Study

Scherrer, Alexandra U; Yang, Wan-Lin; Kouyos, Roger D; Böni, Jürg; Yerly Ferrillo, Sabine; Klimkait, Thomas; Aubert, Vincent; Cavassini, Matthias; Battegay, Manuel; Hauser, Christophe; Calmy, Alexandra; Schmid, Patrick; Bernasconi, Enos; Günthard, Huldrych F

doi:10.1093/infdis/jiw165

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Title		Successful Prevention of Transmission of Integrase Resistance in the Swiss HIV Cohort Study
Authors		Scherrer, Alexandra U Yang, Wan-Lin Kouyos, Roger D Böni, Jürg Yerly Ferrillo, Sabine Klimkait, Thomas Aubert, Vincent Cavassini, Matthias Battegay, Manuel Hauser, Christophe Calmy, Alexandra Schmid, Patrick Bernasconi, Enos Günthard, Huldrych F show all authors [1 - 14]
Published in		The Journal of Infectious Diseases. 2016, vol. 214, no. 3, p. 399-402
Abstract		The prevalence of integrase strand transfer inhibitor (INSTI)-transmitted drug resistance (TDR) may increase with the increasing use of INSTIs. We analyzed the prevalence of INSTI TDR in the Swiss HIV Cohort Study (2008-2014). In 1 of 1316 drug-naive samples (0.1%), a major INSTI TDR mutation was detected. Prevalence was stable, although INSTIs were increasingly used. We showed that this is in contrast to the introduction of previous drug classes, in which more treatment failures with resistant strains occurred and TDR was observed more rapidly. We demonstrated on a population-level that it is possible to avoid TDR to a new drug class for years.
Keywords		Anti-HIV Agents/pharmacology — Cohort Studies — Disease Transmission — Infectious — Drug Resistance — Viral — Drug Utilization — HIV/drug effects/genetics/isolation & purification — HIV Infections/drug therapy/epidemiology/transmission/virology — HIV Integrase/genetics — HIV Integrase Inhibitors/therapeutic use — Humans — Prevalence — Switzerland/epidemiology
Identifiers		DOI: 10.1093/infdis/jiw165 PMID: 27130429
Full text		Article (Published version) (233 Kb) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine
Research groups		Groupe Laurent Kaiser (virologie clinique) (668) VIH/SIDA (930)
Citation (ISO format)		SCHERRER, Alexandra U et al. Successful Prevention of Transmission of Integrase Resistance in the Swiss HIV Cohort Study. In: The Journal of Infectious Diseases, 2016, vol. 214, n° 3, p. 399-402. doi: 10.1093/infdis/jiw165 https://archive-ouverte.unige.ch/unige:98823