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Tracing HIV-1 transmission: envelope traits of HIV-1 transmitter and recipient pairs

Oberle, Corinna S
Joos, Beda
Rusert, Peter
Campbell, Nottania K
Beauparlant, David
Kuster, Herbert
Weber, Jacqueline
Schenkel, Corinne D
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Published in Retrovirology. 2016, vol. 13, no. 1, 62
Abstract Mucosal HIV-1 transmission predominantly results in a single transmitted/founder (T/F) virus establishing infection in the new host despite the generally high genetic diversity of the transmitter virus population. To what extent HIV-1 transmission is a stochastic process or driven by selective forces that allow T/F viruses best to overcome bottlenecks in transmission has not been conclusively resolved. Building on prior investigations that suggest HIV-1 envelope (Env) features to contribute in the selection process during transmission, we compared phenotypic virus characteristics of nine HIV-1 subtype B transmission pairs, six men who have sex with men and three male-to-female transmission pairs.
Keywords Acute DiseaseAntibodiesNeutralizing/blood/immunologyFemaleGenetic VariationHIV Infections/transmission/virologyHIV-1/genetics/isolation & purification/physiologyHomosexualityMaleHumansInterferon-alpha/pharmacologyLeukocytesMononuclear/drug effects/virologyMaleNeutralization TestsPhenotypeSequence AnalysisDNAStochastic ProcessesViral TropismVirus InternalizationEnv Gene ProductsHuman Immunodeficiency Virus/genetics/immunology
PMID: 27595568
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Research group Groupe Laurent Kaiser (virologie clinique) (668)
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OBERLE, Corinna S et al. Tracing HIV-1 transmission: envelope traits of HIV-1 transmitter and recipient pairs. In: Retrovirology, 2016, vol. 13, n° 1, p. 62. doi: 10.1186/s12977-016-0299-0 https://archive-ouverte.unige.ch/unige:98820

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Deposited on : 2017-11-09

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