UNIGE document Scientific Article
previous document  unige:98820  next document
add to browser collection
Title

Tracing HIV-1 transmission: envelope traits of HIV-1 transmitter and recipient pairs

Authors
Oberle, Corinna S
Joos, Beda
Rusert, Peter
Campbell, Nottania K
Beauparlant, David
Kuster, Herbert
Weber, Jacqueline
Schenkel, Corinne D
show hidden authors show all authors [1 - 22]
Published in Retrovirology. 2016, vol. 13, no. 1, p. 62
Abstract Mucosal HIV-1 transmission predominantly results in a single transmitted/founder (T/F) virus establishing infection in the new host despite the generally high genetic diversity of the transmitter virus population. To what extent HIV-1 transmission is a stochastic process or driven by selective forces that allow T/F viruses best to overcome bottlenecks in transmission has not been conclusively resolved. Building on prior investigations that suggest HIV-1 envelope (Env) features to contribute in the selection process during transmission, we compared phenotypic virus characteristics of nine HIV-1 subtype B transmission pairs, six men who have sex with men and three male-to-female transmission pairs.
Keywords Acute DiseaseAntibodiesNeutralizing/blood/immunologyFemaleGenetic VariationHIV Infections/transmission/virologyHIV-1/genetics/isolation & purification/physiologyHomosexualityMaleHumansInterferon-alpha/pharmacologyLeukocytesMononuclear/drug effects/virologyMaleNeutralization TestsPhenotypeSequence AnalysisDNAStochastic ProcessesViral TropismVirus InternalizationEnv Gene ProductsHuman Immunodeficiency Virus/genetics/immunology
Identifiers
PMID: 27595568
Full text
Article (Published version) (3.3 MB) - public document Free access
Structures
Research group Groupe Laurent Kaiser (virologie clinique) (668)
Citation
(ISO format)
OBERLE, Corinna S et al. Tracing HIV-1 transmission: envelope traits of HIV-1 transmitter and recipient pairs. In: Retrovirology, 2016, vol. 13, n° 1, p. 62. https://archive-ouverte.unige.ch/unige:98820

106 hits

40 downloads

Update

Deposited on : 2017-11-09

Export document
Format :
Citation style :