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Effects of gravitational acceleration on cardiovascular autonomic control in resting humans

Pichot, Vincent
Antonutto, Guglielmo
Capelli, Carlo
Published in European Journal of Applied Physiology. 2015, vol. 115, no. 7, p. 1417-1427
Abstract Previous studies of cardiovascular responses in hypergravity suggest increased sympathetic regulation. The analysis of spontaneous heart rate variability (HRV) parameters and spontaneous baroreflex sensitivity (BRS) informs on the reciprocal balance of parasympathetic and sympathetic regulations at rest. This paper was aimed at determining the effects of gravitational acceleration (a g) on HRV and BRS. METHODS: Eleven healthy subjects (age 26.6 ± 6.1) were studied in a human centrifuge at four a g levels (1, 1.5, 2 and 2.5 g) during 5-min sessions at rest. We evaluated spontaneous variability of R-R interval (RR), and of systolic and diastolic blood pressure (SAP and DAP, respectively), by power spectral analysis, and BRS by the sequence method, using the BRSanalysis(®) software. RESULTS: At 2.5 g, compared to 1 g, (1) the total power (P TOT) and the powers of LF and HF components of HRV were lower, while the LF/HF ratio was higher; (2) normalized units for LF and HF did not changed significantly; (3) the P TOT, LF and HF powers of SAP were higher; (4) the P TOT and LF power of DAP were higher; and (5) BRS was decreased. CONCLUSIONS: These results do not agree with the notion of sympathetic up-regulation supported by the increase in HR and DAP (tonic indices), and of SAP and DAP LF powers (oscillatory indices). The P TOT reduction leads to speculate that only the sympathetic branch of the ANS might have been active during elevated a g exposure. The vascular response occurred in a condition of massive baroreceptive unloading
Keywords Heart rate variabilityArterial blood pressureBaroreflexesHuman centrifuge
PMID: 25681109
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Other version: http://link.springer.com/10.1007/s00421-015-3117-9
Research group Métabolisme énergétique (642)
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FONTOLLIET, Timothée Matthieu et al. Effects of gravitational acceleration on cardiovascular autonomic control in resting humans. In: European Journal of Applied Physiology, 2015, vol. 115, n° 7, p. 1417-1427. https://archive-ouverte.unige.ch/unige:98776

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Deposited on : 2017-11-08

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