Scientific Article
previous document  unige:98758  next document
add to browser collection

The association of neurocognitive impairment with diminished expression and apathy in schizophrenia

Hartmann-Riemer, Matthias N
Hager, Oliver M
Kirschner, Matthias
Bischof, Martin
Kluge, Agne
Seifritz, Erich
Published in Schizophrenia Research. 2015, vol. 169, no. 1-3, p. 427-432
Abstract Negative symptoms can be grouped into the two dimensions of diminished expression and apathy, which have been shown to be dissociable regarding external validators, such as functional outcome. Here, we investigated whether these two dimensions differentially relate to neurocognitive impairment in schizophrenia. 47 patients with schizophrenia or schizoaffective disorder and 33 healthy control participants were subjected to a neurocognitive test battery assessing multiple cognitive domains (processing speed, working memory, verbal fluency, verbal learning and memory, mental planning), which are integrated into a composite cognition score. Negative symptoms in patients were assessed using the Brief Negative Symptom Scale. We found that diminished expression significantly related to neurocognitive impairment, while severity of apathy symptoms was not directly associated with neurocognition. Other assessed clinical variables include chlorpromazine equivalents, positive symptoms, and depressive symptoms and did not influence the results. Our results are in line with a cognitive resource limitation model of diminished expression in schizophrenia and indicate that cognitive remediation therapy might be helpful to ameliorate expressive deficits.
Keywords AdultApathy/physiologyCognition Disorders/etiologyFemaleHumansMaleMood Disorders/etiologyNeuropsychological TestsPsychiatric Status Rating ScalesRegression AnalysisSchizophrenia/complicationsSchizophrenic PsychologyStatisticsNonparametricYoung Adult
PMID: 26526750
Full text
Article (Published version) (254 Kb) - public document Free access
(ISO format)
HARTMANN-RIEMER, Matthias N et al. The association of neurocognitive impairment with diminished expression and apathy in schizophrenia. In: Schizophrenia Research, 2015, vol. 169, n° 1-3, p. 427-432. doi: 10.1016/j.schres.2015.10.032

336 hits



Deposited on : 2017-11-08

Export document
Format :
Citation style :