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Title

The modifier of position-effect variegation Suvar(3)7 of Drosophila: there are two alternative transcripts and seven scattered zinc fingers, each preceded by a tryptophan box
Authors
Cléard, Fabienne
Matsarskaia, Marie
Spierer, Pierre
Published in Nucleic Acids Research. 1995, vol. 23, no. 5, p. 796-802
Abstract An increase in the number of copies of the Drosophila locus Suvar(3)7 enhances position-effect variegation, i.e. the inactivation in some cells of genes brought close to heterochromatin by a chromosomal rearrangement. The locus produces two transcripts of 5047 and 4203 nt that differ solely by the length of their 3' untranslated region. That these transcripts encode the modifier of variegation Suvar(3)7 is demonstrated by genetic transformation with the corresponding cDNAs. The deduced protein is 1169 amino acids long and contains seven widely spaced zinc fingers. These fingers are each preceded at 11-16 amino acids before the N-terminal cysteine by a tryptophan-containing motif. The transcripts are maternally transmitted, but are also found throughout development. The ubiquitous distribution of transcripts in embryos and the different sequence motifs support our speculation that the locus encodes a chromosomal protein implicated in heterochromatin-mediated DNA silencing.
Keywords Alternative Splicing — Amino Acid Sequence — Animals — Base Sequence — DNA, Complementary — Drosophila/embryology/genetics — Female — Genomic Imprinting — Molecular Sequence Data — Ovary/metabolism — RNA, Messenger/genetics/metabolism — Transformation, Genetic — Tryptophan/genetics — Zinc Fingers/genetics
Identifiers
PMID: 7708496
Full text
Article (Published version) (1.8 MB) - public document Free access
Structures
Faculté des sciences / Section de biologie / Département de génétique et évolution
Citation
(ISO format) 		CLÉARD, Fabienne, MATSARSKAIA, Marie, SPIERER, Pierre. The modifier of position-effect variegation Suvar(3)7 of Drosophila: there are two alternative transcripts and seven scattered zinc fingers, each preceded by a tryptophan box. In: Nucleic Acids Research, 1995, vol. 23, n° 5, p. 796-802. https://archive-ouverte.unige.ch/unige:9870

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Deposited on : 2010-08-06

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