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Pityriasis rubra pilaire : une dermatose mal connue

Published in Revue médicale suisse. 2016, vol. 12, no. 512, p. 653-7
Abstract Pityriasis rubra pilaris is a rare heterogeneous disorder characterized by follicular keratosis, perifollicular erythema and palmoplantar hyperkeratosis. The aetiology is still unknown. In the majority of cases some triggering factors are found such as trauma or bacterial infection, possibly on a predisposed condition. In other cases, some immunological disorders are associated, and in familial cases a genetic disorder of keratinization has been suggested. The evolution is variable according to the clinical type. The treatment is not well defined, and there is a lack of clinical trials. The best results however are obtained with oral retinoids, methotrexate or ciclosporine as alternative therapy. New TNF inhibitors and anti-IL-12/23 showed a good result and could be have interest in the future.
Keywords AdministrationTopicalBiological Products/administration & dosageCyclosporine/therapeutic useDermatologic Agents/administration & dosageDiagnosisDifferentialHumansMethotrexate/therapeutic usePhototherapy/methodsPityriasis Rubra Pilaris/diagnosis/etiology/therapyRetinoids/therapeutic use
PMID: 27172696
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Research group Mécanismes des pathologies de l'inflammation cutanée (919)
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QUENAN, Sandrine, LAFFITTE, Emmanuel Alexis. Pityriasis rubra pilaire : une dermatose mal connue. In: Revue médicale suisse, 2016, vol. 12, n° 512, p. 653-7. https://archive-ouverte.unige.ch/unige:98668

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Deposited on : 2017-11-07

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