Modifiers of position-effect variegation in the region from 86C to 88B of the <i>Drosophila melanogaster</i> third chromosome

Reuter, Günther; Gausz, Janos; Gyurkovics, Henric; Friede, B.; Bang, R.; Spierer-Royer, Anne; Hall, Lucinda M. C.; Spierer, Pierre

doi:10.1007/BF00327193

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unige:9864

Title
Modifiers of position-effect variegation in the region from 86C to 88B of the Drosophila melanogaster third chromosome

Authors
Reuter, Günther
Gausz, Janos
Gyurkovics, Henric
Friede, B.
Bang, R.
Spierer-Royer, Anne
Hall, Lucinda M. C.
Spierer, Pierre

Published in Molecular and General Genetics. 1987, vol. 210, no. 3, p. 429-36

Abstract Four dominant suppressor and one enhancer of variegation loci were mapped in the polytene chromosome region extending from section 86C to section 88B of the Drosophila melanogaster third chromosome using a set of deficiencies. The suppressor locus Su-var(3)14 maps in 86CD, Su-var(3)13 in 86F4-7, Su-var(3)6 in 87B4-7 and Su-var(3)7 in 87E4-5. The enhancer locus E-var(3)3 maps in 87E12-F11. Su-var(3)13, Su-var(3)6 and Su-var(3)7 are also defined by point mutant alleles originally identified by other criteria (Reuter et al. 1986). Duplications covering the suppressor loci Su-var(3)14, Su-var(3)13, Su-var(3)6 and Su-var(3)7 were found to reduce considerably the haplo-abnormal effect of heterozygous point mutants of the corresponding loci. One suppressor locus, Su-var(3)7, maps within a region which has previously been cloned. The positions of deficiency breakpoints delimiting the suppressor locus indicate that all the necessary sequences for its function are located within 10 kb of cloned DNA.

Keywords Animals — Chromosome Mapping — Chromosomes/ultrastructure — Cloning, Molecular — Drosophila melanogaster/genetics — Gene Expression Regulation — Genetic Complementation Test — Suppression, Genetic — Transcription, Genetic

Identifiers
DOI: 10.1007/BF00327193
PMID: 3123888

Full text
Article (Published version) (1.1 MB) - Free access

Structures
Faculté des sciences / Section de biologie / Département de biologie moléculaire

Citation
(ISO format) REUTER, Günther et al. Modifiers of position-effect variegation in the region from 86C to 88B of the Drosophila melanogaster third chromosome. In: Molecular and General Genetics, 1987, vol. 210, n° 3, p. 429-36. doi: 10.1007/BF00327193 https://archive-ouverte.unige.ch/unige:9864

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Modifiers of position-effect variegation in the region from 86C to 88B of the Drosophila melanogaster third chromosome

Title		Modifiers of position-effect variegation in the region from 86C to 88B of the Drosophila melanogaster third chromosome
Authors		Reuter, Günther Gausz, Janos Gyurkovics, Henric Friede, B. Bang, R. Spierer-Royer, Anne Hall, Lucinda M. C. Spierer, Pierre
Published in		Molecular and General Genetics. 1987, vol. 210, no. 3, p. 429-36
Abstract		Four dominant suppressor and one enhancer of variegation loci were mapped in the polytene chromosome region extending from section 86C to section 88B of the Drosophila melanogaster third chromosome using a set of deficiencies. The suppressor locus Su-var(3)14 maps in 86CD, Su-var(3)13 in 86F4-7, Su-var(3)6 in 87B4-7 and Su-var(3)7 in 87E4-5. The enhancer locus E-var(3)3 maps in 87E12-F11. Su-var(3)13, Su-var(3)6 and Su-var(3)7 are also defined by point mutant alleles originally identified by other criteria (Reuter et al. 1986). Duplications covering the suppressor loci Su-var(3)14, Su-var(3)13, Su-var(3)6 and Su-var(3)7 were found to reduce considerably the haplo-abnormal effect of heterozygous point mutants of the corresponding loci. One suppressor locus, Su-var(3)7, maps within a region which has previously been cloned. The positions of deficiency breakpoints delimiting the suppressor locus indicate that all the necessary sequences for its function are located within 10 kb of cloned DNA.
Keywords		Animals — Chromosome Mapping — Chromosomes/ultrastructure — Cloning, Molecular — Drosophila melanogaster/genetics — Gene Expression Regulation — Genetic Complementation Test — Suppression, Genetic — Transcription, Genetic
Identifiers		DOI: 10.1007/BF00327193 PMID: 3123888
Full text		Article (Published version) (1.1 MB) - Free access
Structures		Faculté des sciences / Section de biologie / Département de biologie moléculaire
Citation (ISO format)		REUTER, Günther et al. Modifiers of position-effect variegation in the region from 86C to 88B of the Drosophila melanogaster third chromosome. In: Molecular and General Genetics, 1987, vol. 210, n° 3, p. 429-36. doi: 10.1007/BF00327193 https://archive-ouverte.unige.ch/unige:9864