Ammonium tetrathiomolybdate following ischemia/reperfusion injury: Chemistry, pharmacology, and impact of a new class of sulfide donor in preclinical injury models

Dyson, Alex; Dal-Pizzol, Felipe; Sabbatini, Giovanni; Lach, Anna B; Galfo, Federica; Dos Santos Cardoso, Juliano; Pescador Mendonça, Bruna; Hargreaves, Iain; Bollen Pinto, Bernardo; Bromage, Daniel I; Martin, John F; Moore, Kevin P; Feelisch, Martin; Singer, Mervyn

doi:10.1371/journal.pmed.1002310

Scientific article

English

Ammonium tetrathiomolybdate following ischemia/reperfusion injury: Chemistry, pharmacology, and impact of a new class of sulfide donor in preclinical injury models

ContributorsDyson, Alex; Dal-Pizzol, Felipe; Sabbatini, Giovanni; Lach, Anna B; Galfo, Federica; Dos Santos Cardoso, Juliano; Pescador Mendonça, Bruna; Hargreaves, Iain; Bollen Pinto, Bernardo

; Bromage, Daniel I; Martin, John F; Moore, Kevin P; Feelisch, Martin; Singer, Mervyn

Published inPLOS Medicine, vol. 14, no. 7, e1002310

Publication date2017

Abstract

Early revascularization of ischemic organs is key to improving outcomes, yet consequent reperfusion injury may be harmful. Reperfusion injury is largely attributed to excess mitochondrial production of reactive oxygen species (ROS). Sulfide inhibits mitochondria and reduces ROS production. Ammonium tetrathiomolybdate (ATTM), a copper chelator, releases sulfide in a controlled and novel manner, and may offer potential therapeutic utility.

Keywords

Animals
Chelating Agents/pharmacology
Male
Molybdenum/pharmacology
Rats
Rats Wistar
Reperfusion Injury/drug therapy

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences

Research groups

Groupe de recherche en hémodynamique (913)

Citation (ISO format)

DYSON, Alex et al. Ammonium tetrathiomolybdate following ischemia/reperfusion injury: Chemistry, pharmacology, and impact of a new class of sulfide donor in preclinical injury models. In: PLOS Medicine, 2017, vol. 14, n° 7, p. e1002310. doi: 10.1371/journal.pmed.1002310