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Title

Ammonium tetrathiomolybdate following ischemia/reperfusion injury: Chemistry, pharmacology, and impact of a new class of sulfide donor in preclinical injury models

Authors
Dyson, Alex
Dal-Pizzol, Felipe
Sabbatini, Giovanni
Lach, Anna B
Galfo, Federica
Dos Santos Cardoso, Juliano
Pescador Mendonça, Bruna
Hargreaves, Iain
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Published in PLOS Medicine. 2017, vol. 14, no. 7, p. e1002310
Abstract Early revascularization of ischemic organs is key to improving outcomes, yet consequent reperfusion injury may be harmful. Reperfusion injury is largely attributed to excess mitochondrial production of reactive oxygen species (ROS). Sulfide inhibits mitochondria and reduces ROS production. Ammonium tetrathiomolybdate (ATTM), a copper chelator, releases sulfide in a controlled and novel manner, and may offer potential therapeutic utility.
Keywords AnimalsChelating Agents/pharmacologyMaleMolybdenum/pharmacologyRatsRats WistarReperfusion Injury/drug therapy
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PMID: 28678794
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Article (Published version) (11.4 MB) - public document Free access
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Research group Groupe de recherche en hémodynamique (913)
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DYSON, Alex et al. Ammonium tetrathiomolybdate following ischemia/reperfusion injury: Chemistry, pharmacology, and impact of a new class of sulfide donor in preclinical injury models. In: PLOS Medicine, 2017, vol. 14, n° 7, p. e1002310. https://archive-ouverte.unige.ch/unige:98624

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Deposited on : 2017-11-07

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